Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction.

Journal of Zhejiang University. Science. B Pub Date : 2023-04-15 DOI:10.1631/jzus.B2200459

Jingru Li, Haocheng Ma, Xinyu Wu, Guihu Sun, Ping Yang, Yunzhu Peng, Qixian Wang, Luqiao Wang

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引用次数: 1

Abstract

Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.

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非外泌体和外泌体非编码rna在心肌梗死的调控机制和诊断生物标志物中的重要作用。

非外泌体非编码rna (non-exo-ncRNAs)和外泌体ncRNAs (exo-ncRNAs)与心肌梗死(MI)的病理发展相关。因此，本分析综述综述了当前关于血浆非外显子/外显子ncrna作用的MI研究。我们总结了ncrna的特征和关键作用，并通过生物信息学分析揭示了它们之间新的生物学相关性。以下贡献:(1)我们全面描述了MI的表达谱、竞争内源性RNA (ceRNA)网络和非exo/exo- ncrna的“坏死前”生物标志物;(2)功能富集分析表明，ncRNAs靶基因在调控凋亡信号通路和细胞对化学胁迫的反应等方面富集;(3)我们对非exo/exo- ncrna在心肌梗死中的机制、病理生理和生物标志物作用提出了更新和全面的看法，从而为心肌梗死的临床管理提供理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Zhejiang University. Science. B

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