Perinatal Metal and Metalloid Exposures and Offspring Cardiovascular Health Risk.

IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Current Environmental Health Reports Pub Date : 2022-12-01 Epub Date: 2022-08-18 DOI:10.1007/s40572-022-00377-1
Gyeyoon Yim, Lorena Reynaga, Velia Nunez, Caitlin G Howe, Megan E Romano, Yu Chen, Margaret R Karagas, Claudia Toledo-Corral, Shohreh F Farzan
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Abstract

Purpose of review: Toxic metal exposures have been associated with cardiovascular disease in adults and growing evidence suggests metal exposures also adversely affect cardiovascular phenotypes in childhood and adolescence. However, to our knowledge, the influence of perinatal metals exposure, particularly metal mixtures, in relation to cardiovascular-related outcomes have not been comprehensively reviewed.

Recent findings: We summarized 17 contemporary studies (2017-2021) that investigated the impact of perinatal metal exposures on measures of cardiovascular health in children. Accumulating evidence supports a potential adverse impact of perinatal Pb exposure on BP in children. Fewer recent studies have focused on perinatal As, Hg, and Cd; thus, the cardiovascular impacts of these metals are less clear. Studies of metal mixtures demonstrate that interactions between metals may be complex and have identified numerous understudied elements and essential metals, including Mo, Co, Ni, Se, Zn, and Mn, which may influence cardiovascular risk. A key question that remains is whether perinatal metals exposure influences cardiovascular health into adulthood. Comparisons across studies remain challenging due to several factors, including differences in the timing of exposure/outcome assessments and exposure biomarkers, as well as variability in exposure levels and mixture compositions across populations. Future studies longitudinally investigating trajectories of cardiovascular outcomes could help determine the influence of perinatal metals exposure on long-term effects of clinical relevance in later life and whether interventions, which reduce metals exposures during this key developmental window, could alter disease development.

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围产期金属和类金属暴露与后代心血管健康风险。
综述的目的:有毒金属暴露与成人心血管疾病有关,越来越多的证据表明,金属暴露也会对儿童和青少年的心血管表型产生不利影响。然而,据我们所知,围产期金属暴露,尤其是金属混合物,对心血管相关结果的影响尚未得到全面审查:我们总结了 17 项当代研究(2017-2021 年),这些研究调查了围产期金属暴露对儿童心血管健康指标的影响。不断积累的证据支持围产期铅暴露对儿童血压的潜在不利影响。最近对围产期砷、汞和镉的研究较少,因此这些金属对心血管的影响尚不明确。对金属混合物的研究表明,金属之间的相互作用可能很复杂,并发现了许多未被充分研究的元素和基本金属,包括可能影响心血管风险的钼、钴、镍、硒、锌和锰。一个仍然存在的关键问题是,围产期金属暴露是否会影响成年后的心血管健康。由于暴露/结果评估和暴露生物标志物的时间不同,以及不同人群暴露水平和混合物成分的差异等多种因素,对不同研究进行比较仍具有挑战性。未来纵向调查心血管结果轨迹的研究将有助于确定围产期金属暴露对日后临床相关长期影响的影响,以及在这一关键发育窗口期减少金属暴露的干预措施是否能改变疾病的发展。
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来源期刊
CiteScore
13.60
自引率
1.30%
发文量
47
期刊介绍: Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.
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