Plasma amino acids by age and gender in Hangzhou, Eastern China.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2023-01-01 DOI:10.6133/apjcn.202306_32(2).0009
Xiaojie He, Meixuan Liu, Xiaoqi Li, Ting Sun, Xingang Wang
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Abstract

Background and objectives: Amino acids (AAs) are crucial nutrients and fundamental building blocks of organisms that can be utilized to assess nutritional status and detect diseases. However, insufficient information has been reported on plasma AA in the Eastern Chinese population.

Methods and study design: 1859 persons who underwent physical examination in our hospital from January to December 2020 were enrolled. Plasma AA levels were determined by ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS.), and the effects of age and sex on 19 plasma AA profiles were analyzed. The Python language was used for data analysis and graphic visualization.

Results: Plasma arginine, proline, threonine, as-paragine, phenylalanine, and glycine in males, and plasma lysine, leucine, proline, valine, isoleucine, alanine, tyrosine, phenylalanine, and hydroxyproline levels in females increased with age. The 2-aminobutyric acid and serine levels in both sexes, and isoleucine, valine, leucine, and histidine levels in males decreased with age. Glycine level was higher in females than in males, and other 17 AAs except arginine and aspartate were higher in males than in females.

Conclusions: Our study indicated that plasma AA levels can reflect the nutritional status and dietary structure of the population, with high obesity rate and high incidence of chronic diseases in eastern China. Age has certain effects on plasma AA levels, especially compared with sex.

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中国东部杭州市人群血浆氨基酸的年龄和性别。
背景和目的:氨基酸(AAs)是生物体的重要营养素和基本组成部分,可用于评估营养状况和检测疾病。然而,关于中国东部人群血浆AA的信息报道不足。方法和研究设计:纳入2020年1月至12月在我院体检的1859人。采用超高效液相色谱-质谱法(UPLC-MS/ ms)测定血浆AA水平,分析年龄和性别对19种血浆AA谱的影响。使用Python语言进行数据分析和图形可视化。结果:男性血浆精氨酸、脯氨酸、苏氨酸、代谢氨酸、苯丙氨酸、甘氨酸,女性血浆赖氨酸、亮氨酸、脯氨酸、缬氨酸、异亮氨酸、丙氨酸、酪氨酸、苯丙氨酸、羟脯氨酸水平随年龄增长而升高。两性的2-氨基丁酸和丝氨酸水平以及男性的异亮氨酸、缬氨酸、亮氨酸和组氨酸水平随着年龄的增长而下降。除精氨酸和天冬氨酸外,其余17种氨基酸男性高于女性。结论:我们的研究表明,血浆AA水平可以反映中国东部地区高肥胖率和慢性病高发人群的营养状况和饮食结构。年龄对血浆AA水平有一定的影响,尤其是与性别相比。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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