Identification and molecular characterization of Orf virus infection in occupationally exposed women in South America

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-04-01 DOI:10.1016/j.ram.2022.07.002

Andrea Peralta , Carlos Flores-Olivares , Andrea Verna , Erika González-Altamiranda , Ernesto Odriozola , Carolina Madariaga , Anselmo Odeón , Guido A. König , Germán Cantón

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Abstract

Contagious Ecthyma (CE) is a severe exanthematous dermatitis caused by the Orf virus (ORFV) that mainly affects domestic small ruminants such as sheep and goats. It is a worldwide-distributed occupational zoonosis, particularly infecting those in close contact with animals or animal products such as shepherds, farmers and veterinarians, among others. In the present work, we report the first human CE case confirmed in Argentina. A phylogenetic analysis based on four gene sequences of the isolated strain responsible for the disease showed that this isolate grouped with other ORFV sequences that caused reported CE cases in sheep from the same Argentine province. We also sequenced a sample from a Chilean human case reported in 2017, whose phylogenetic analysis showed that it groups together with other Argentine isolates from locations close to the border with Chile.

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南美职业暴露妇女口蹄疫病毒感染的鉴定和分子特征

传染性湿疹(CE)是由口蹄疫病毒(ORFV)引起的一种严重的疹性皮炎，主要影响绵羊和山羊等家养小反刍动物。这是一种世界范围内分布的职业性人畜共患病，特别是感染与动物或动物产品密切接触的人，如牧羊人、农民和兽医等。在目前的工作中，我们报告了阿根廷确诊的第一例人类CE病例。对导致该疾病的分离株的4个基因序列进行系统发育分析表明，该分离株与阿根廷同一省报告的引起绵羊CE病例的其他ORFV序列属于一类。我们还对2017年报告的智利一例人类病例的样本进行了测序，其系统发育分析显示，它与来自智利边境附近地区的其他阿根廷分离株属于同一类。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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