Impact of X-Ray Exposure From Computed Tomography on Wearable Insulin Delivery Devices.

IF 4.1 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Science and Technology Pub Date : 2024-11-01 Epub Date: 2023-04-26 DOI:10.1177/19322968231169722
Frank Dong, Paul Johnson, Grant Fong, Alex Nguyen, Felipe Lauand, Todd Vienneau
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Abstract

Background: To investigate the impact of radiation exposure from a computed tomography (CT) scanner on the functional integrity of a wearable insulin delivery system.

Methods: A total of 160 Omnipods and four personal diabetes managers (PDMs) were evenly divided into four groups: (1) control group (no radiation exposure), (2) typical radiation exposure group, (3) 4× typical radiation exposure group, and (4) scatter radiation group. Pods were attached to an anthropomorphic torso phantom on the abdomen (direct irradiation) or shoulder (scatter radiation) region. A third-generation dual-source CT scanner was used to scan the pods using either a typical exposure (used for routine CT abdominal study of a median size patient) or 4× typical exposure. A manufacturer-recommended 20-step functionality test was performed for all 160 Omnipods.

Results: The radiation dose (measured in volume CT Dose index) was 16 mGy for a typical exposure, and 64 mGy for 4× typical exposure. The scatter radiation is less than 0.1 mGy. All Pods passed the functionality test except one pod in the scatter radiation group, which sounded an alarm due to occlusion. The blockage to the fluid was due to a kink in the soft cannula, a mechanical issue not caused by the radiation exposure.

Conclusions: This study suggests X-ray exposure levels used in radiological imaging procedures do not negatively impact the functional integrity of Omnipods. This finding may support the potential for the manufacturer to remove the warning that patients should remove the Pod for X-ray imaging procedures, which will have a huge impact on patient care.

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计算机断层扫描产生的 X 射线辐射对可穿戴式胰岛素输送设备的影响。
背景:研究计算机断层扫描(CT)对可穿戴胰岛素输送系统功能完整性的影响:研究计算机断层扫描(CT)辐射对可穿戴胰岛素输送系统功能完整性的影响:方法:将 160 个 Omnipod 和 4 个个人糖尿病管理器 (PDM) 平均分成四组:(1) 对照组(无辐照)、(2) 典型辐照组、(3) 4 倍典型辐照组和 (4) 散射辐照组。腹部(直接照射)或肩部(散射辐射)区域的荚膜被固定在拟人躯干模型上。使用第三代双源 CT 扫描仪对吊舱进行扫描,采用典型照射(用于对中等体型患者进行常规腹部 CT 研究)或 4 倍典型照射。对所有 160 个 Omnipod 进行了制造商推荐的 20 步功能测试:结果:典型照射的辐射剂量(以容积 CT 剂量指数衡量)为 16 mGy,4 倍典型照射的辐射剂量为 64 mGy。散射辐射小于 0.1 mGy。除散射辐射组的一个 pod 因堵塞发出警报外,其他所有 pod 均通过了功能测试。液体堵塞的原因是软套管扭结,这是一个机械问题,并非由辐射照射造成:这项研究表明,放射成像程序中使用的 X 射线照射水平不会对 Omnipod 的功能完整性产生负面影响。这一发现可能支持制造商取消患者在进行 X 射线成像程序时应摘下花苞的警告,这将对患者护理产生巨大影响。
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来源期刊
Journal of Diabetes Science and Technology
Journal of Diabetes Science and Technology Medicine-Internal Medicine
CiteScore
7.50
自引率
12.00%
发文量
148
期刊介绍: The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.
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