Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis.

IF 2.1 4区生物学 Q4 CELL BIOLOGY European Journal of Histochemistry Pub Date : 2023-01-11 DOI:10.4081/ejh.2023.3570

Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang

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引用次数: 1

Abstract

Neurokinin-1 receptor (NK1R) belongs to tachykinin receptor family. Recent studies have suggested that NK1R was upregulated in cancer tissues including breast cancer, glioma and melanoma. Furthermore, NK1R antagonists have been employed to exert anti-tumor effect and promote cancer cell apoptosis. However, the role of NK1R in cervical cancer remains largely unknown. In this study, we aimed to detect the expression of NK1R in cervical cancer and evaluate the anti-tumor effects of NK1R antagonist on cervical cancer cells. We found that NK1R was highly expressed in cervical cancer tissues than in adjacent normal cervical tissues. Furthermore, by using NK1R antagonist we demonstrated that NK1R antagonist inhibited the viability and induced the apoptosis of cervical cancer cells in a dose-dependent manner, and the mechanism may be related to the inhibition of ERK activation and the regulation of apoptosis proteins Bcl-2 and BAX. In conclusion, these findings suggest that NK1R plays an oncogenic role in cervical cancer and is a promising target for cervical cancer therapy.

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神经激肽-1受体在宫颈癌中高表达，其拮抗剂可诱导宫颈癌细胞凋亡。

神经激肽-1受体(Neurokinin-1 receptor, NK1R)属于快激肽受体家族。最近的研究表明，NK1R在乳腺癌、胶质瘤和黑色素瘤等癌症组织中表达上调。此外，NK1R拮抗剂已被用于发挥抗肿瘤作用和促进癌细胞凋亡。然而，NK1R在宫颈癌中的作用在很大程度上仍然未知。在本研究中，我们旨在检测NK1R在宫颈癌中的表达，并评估NK1R拮抗剂对宫颈癌细胞的抗肿瘤作用。我们发现NK1R在宫颈癌组织中的表达高于相邻正常宫颈组织。此外，通过使用NK1R拮抗剂，我们发现NK1R拮抗剂抑制宫颈癌细胞活力并诱导凋亡呈剂量依赖性，其机制可能与抑制ERK活化、调节凋亡蛋白Bcl-2和BAX有关。总之，这些发现表明NK1R在宫颈癌中起致瘤作用，是宫颈癌治疗的一个有希望的靶点。

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来源期刊

European Journal of Histochemistry 生物-细胞生物学

CiteScore

3.70

自引率

5.00%

发文量

审稿时长

3 months

期刊介绍： The Journal publishes original papers concerning investigations by histochemical and immunohistochemical methods, and performed with the aid of light, super-resolution and electron microscopy, cytometry and imaging techniques. Coverage extends to: functional cell and tissue biology in animals and plants; cell differentiation and death; cell-cell interaction and molecular trafficking; biology of cell development and senescence; nerve and muscle cell biology; cellular basis of diseases. The histochemical approach is nowadays essentially aimed at locating molecules in the very place where they exert their biological roles, and at describing dynamically specific chemical activities in living cells. Basic research on cell functional organization is essential for understanding the mechanisms underlying major biological processes such as differentiation, the control of tissue homeostasis, and the regulation of normal and tumor cell growth. Even more than in the past, the European Journal of Histochemistry, as a journal of functional cytology, represents the venue where cell scientists may present and discuss their original results, technical improvements and theories.