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{"title":"Exercise in the Prevention and Treatment of Type 2 Diabetes.","authors":"John P Kirwan, Elizabeth C Heintz, Candida J Rebello, Christopher L Axelrod","doi":"10.1002/cphy.c220009","DOIUrl":null,"url":null,"abstract":"<p><p>Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control. © 2023 American Physiological Society. Compr Physiol 13:1-27, 2023.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220009","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control. © 2023 American Physiological Society. Compr Physiol 13:1-27, 2023.
运动对2型糖尿病的预防和治疗。
2型糖尿病是一种全身性、多因素疾病，是全球发病率和死亡率的主要原因。尽管可用的药物和治疗方法越来越多，但由于在一般人群中已建立的安全性、有效性和耐受性，运动仍然是一线预防和干预策略。本文综述了2型糖尿病的易感危险因素、预防、病理生理和治疗。我们强调关键的细胞和分子适应过程，这些过程为我们对如何、何时以及何种类型的运动可以改善血糖控制提供了深入的了解。©2023美国生理学会。物理学报(自然科学版)，2023(3):1145 - 1145。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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