Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series.

IF 1.3 Q2 VETERINARY SCIENCES Veterinary Record Open Pub Date : 2023-06-13 eCollection Date: 2023-06-01 DOI:10.1002/vro2.63
Sarah Butterfield, Danielle Whittaker, Joana Tabanez, Jordina Caldero Carrete, Clare Pitchford, Charles R J Mattias, Abbe Crawford, Clare Rusbridge
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Abstract

Background: There is limited published information to guide the clinical management of bacterial meningitis/encephalitis in dogs.

Methods: This was a retrospective case series comprising 10 French bulldogs from two referral centres. The cases were diagnosed with bacterial meningitis/encephalitis suspected secondary to otogenic infection based on detection of abnormal fluid/soft tissue opacity within the middle/inner ear, associated meningeal/intracranial involvement through MRI, the findings of cerebro-spinal fluid (CSF) analysis suggestive of sepsis and/or clinical improvement following antibiosis.

Results: Ten dogs were included (three female and seven male), with a median age of 60 months. Dogs presented with acute onset (median 2 days), progressive history of vestibular signs and/or intra-oral or cervical pain. Five dogs had gross signs of concurrent otitis externa. Common MRI findings included material within the tympanic bulla with adjacent meningeal enhancement. Analysis of CSF documented pleocytosis in all eight dogs, intracellular bacteria seen in three with positive bacteriological culture in two dogs. One dog was euthanised following diagnosis. Nine remaining dogs received antimicrobial therapy and six underwent surgical management. Three dogs treated surgically were neurologically normal within 2 weeks and the remaining three improved. Two dogs treated medically improved and one had complete resolution reported within a 4-week follow-up period. Study limitations include its retrospective nature and small sample size with minimal longer term follow-up.

Conclusions: Bacterial meningitis/encephalitis in French bulldogs can require both medical and surgical treatment to achieve a favourable outcome.

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10 只法国斗牛犬继发于耳源性感染的细菌性脑膜炎:回顾性病例系列。
背景:用于指导犬细菌性脑膜炎/脑炎临床治疗的公开信息十分有限:这是一个回顾性病例系列,包括来自两个转诊中心的 10 只法国斗牛犬。这些病例被诊断为疑似继发于耳源性感染的细菌性脑膜炎/脑炎,诊断依据是中耳/内耳内发现异常液体/软组织混浊,通过核磁共振成像发现脑膜/颅内受累,脑脊液(CSF)分析结果提示败血症和/或抗生素治疗后临床症状改善:共纳入 10 只狗(3 只雌性,7 只雄性),中位年龄为 60 个月。病犬起病急(中位 2 天),逐渐出现前庭症状和/或口内或颈部疼痛。五只狗有并发外耳道炎的大体体征。常见的磁共振成像结果包括鼓室内的物质和邻近的脑膜强化。对脑脊液的分析表明,所有八只狗的脑脊液中都有多细胞,三只狗的脑脊液中可见细胞内细菌,两只狗的细菌培养呈阳性。一只狗在确诊后被安乐死。其余九只狗接受了抗菌治疗,六只狗接受了手术治疗。接受手术治疗的三只狗在两周内神经系统恢复正常,其余三只狗的情况有所改善。两只接受药物治疗的狗病情有所好转,其中一只在 4 周的随访期内完全康复。该研究的局限性包括其回顾性和样本量小,长期随访极少:法国斗牛犬细菌性脑膜炎/脑炎可能需要药物治疗和手术治疗才能取得良好的疗效。
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来源期刊
Veterinary Record Open
Veterinary Record Open VETERINARY SCIENCES-
CiteScore
3.00
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.
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