Epidemiology and genetics of early onset colorectal cancer—African overview with a focus on Ethiopia

IF 3 3区 医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2023-02-01 DOI:10.1053/j.seminoncol.2023.03.007
Chimaobi Anugwom , Grace Braimoh , Amir Sultan , Willie Mohammed Johnson , Jose D. Debes , Abdulsemed Mohammed
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引用次数: 1

Abstract

Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia.

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早期结直肠癌的流行病学和遗传学——以埃塞俄比亚为重点的非洲综述
结直肠癌癌症(CRC)是全球癌症相关死亡的常见原因,在撒哈拉以南非洲,晚期诊断率高,死亡率增加。此外,全球早发癌症(EOCRC)的发病率呈惊人的上升趋势,因此需要在一般和特殊人群中进行早期筛查。然而,关于资源贫乏国家,特别是非洲EOCRC的发病率和遗传特征的可用数据有限。此外,根据资源丰富国家的数据提出的建议和机制是否适用于世界其他地区也不明确。在这篇综述中,我们评估了有关EOCRC的文献、其总体发病率和遗传成分,因为它与撒哈拉以南非洲有关。此外,我们强调了埃塞俄比亚EOCRC队列的流行病学和表观遗传学发现。
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来源期刊
Seminars in oncology
Seminars in oncology 医学-肿瘤学
CiteScore
6.60
自引率
0.00%
发文量
58
审稿时长
104 days
期刊介绍: Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.
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