First episode psychosis and weight gain a longitudinal perspective in Cheshire UK: a comparison between individuals with nonaffective versus affective psychosis.

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Endocrinology & Metabolism Pub Date : 2023-09-01 DOI:10.1097/XCE.0000000000000286
Adrian H Heald, Mike Stedman, Chris Daly, John Julian Warner-Levy, Mark Livingston, Lamiece Hussain, Simon Anderson
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Abstract

Early weight gain following initiation of antipsychotic treatment predicts longer-term weight gain, with attendant long-term consequences including premature cardiovascular events/death. An important question is whether there is a difference in weight change over time between people with affective versus nonaffective psychosis. Here we describe the results of a real-world analysis of the BMI change in the months postdiagnosis with affective versus nonaffective psychosis.

Methods: We undertook an anonymised search across one Primary Care Network in Cheshire, UK with a total population of 32 301 individuals. We reviewed the health records of anyone who had been diagnosed over a 10-year period between June 2012 and June 2022 for the first time with first episode nonaffective psychosis versus psychosis associated with depression or bipolar affective disorder (affective psychosis).

Results: The overall % change in BMI was +8% in nonaffective psychosis individuals and +4% in those with a diagnosis of affective psychosis - however, the distribution was markedly skewed for nonaffective psychosis patients. Using caseness as >30% increase in BMI; affective = 4% cases and nonaffective = 13% cases, there was a three-fold difference in terms of increase in BMI. In regression analysis, the r2 linking the initial BMI to % change in BMI was 0.13 for nonaffective psychosis and 0.14 for affective psychosis.

Conclusion: The differences observed here in the distribution of weight change over time between individuals with affective versus nonaffective psychosis may relate to underlying constitutional differences. The phenotypic and genetic factors underlying this difference remain to be defined.

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英国柴郡首次发作精神病和体重增加的纵向视角:非情感性精神病与情感性精神病个体的比较。
开始抗精神病药物治疗后早期体重增加预示着长期体重增加,伴随的长期后果包括过早的心血管事件/死亡。一个重要的问题是,情感性和非情感性精神病患者之间的体重变化是否随时间而有所不同。在这里,我们描述了对情感性和非情感性精神病诊断后几个月BMI变化的现实分析结果。方法:我们在英国柴郡的一个初级保健网络中进行了匿名搜索,共有32301人。我们回顾了2012年6月至2022年6月10年间首次被诊断为首发非情感性精神病与抑郁症或双相情感障碍(情感性精神病)相关精神病的任何人的健康记录。结果:非情感性精神病患者BMI的总体变化百分比为+8%,情感性精神病患者BMI的总体变化百分比为+4%,然而,非情感性精神病患者的分布明显偏倚。以BMI增加>30%为病例;情感= 4%的病例和非情感= 13%的病例,在BMI增加方面有三倍的差异。在回归分析中,非情感性精神病患者的初始BMI与BMI变化百分比的r2为0.13,情感性精神病患者的r2为0.14。结论:本文观察到的情感性与非情感性精神病患者体重随时间变化的差异可能与潜在的体质差异有关。这种差异背后的表型和遗传因素仍有待确定。
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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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