Treatment after failure of frontline therapy of chronic myeloid leukemia in chronic phase including allogeneic hematopoietic stem cell transplantation.

IF 2.3 Q2 HEMATOLOGY Blood Research Pub Date : 2023-04-30 DOI:10.5045/br.2023.2023054
Jieun Uhm
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引用次数: 1

Abstract

The treatment outcomes of chronic myeloid leukemia in chronic phase (CML-CP) have dramatically improved with comparable life-expectancy to average of general population in tyrosine kinase inhibitor (TKI) era. However, less than a half of patients who started with TKI can remain on frontline TKI. The reasons of switching TKI can be either intolerance or the lack of efficacy. Although a kinase domain (KD) mutation can guide to select salvage TKI from the point of view on the efficacy of TKIs, many factors need to be considered before choosing next-line TKI such as the high-risk features of CML, the adverse events with prior TKI, and the comorbidities of patients. The therapeutic options for CML-CP after failing frontline TKI due to treatment failure or suboptimal responses will be reviewed including allogeneic hematopoietic stem cell transplantation.

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慢性髓系白血病慢性期一线治疗失败后的治疗包括异基因造血干细胞移植。
在酪氨酸激酶抑制剂(TKI)时代,慢性髓系白血病(CML-CP)的治疗结果显著改善,预期寿命与普通人群的平均寿命相当。然而,只有不到一半的TKI患者能够坚持一线TKI治疗。切换TKI的原因可能是不耐受或缺乏疗效。虽然激酶结构域(KD)突变可以从TKI疗效的角度指导补救性TKI的选择,但在选择下一线TKI时需要考虑许多因素,如CML的高危特征、既往TKI的不良事件、患者的合并症等。在一线TKI治疗失败或反应欠佳后,CML-CP的治疗选择将包括异体造血干细胞移植。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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