Neural Correlates of Tooth Clenching in Patients with Bruxism and Temporomandibular Disorder-Related Pain.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-02-01 DOI:10.11607/ofph.3091

Theo Jm Kluskens, Peter Awh Kessler, Bernadette M Jansma, Amanda Kaas, Vincent van de Ven

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Abstract

Aims: To measure brain activity in patients with bruxism and temporomandibular disorder (TMD)-related pain in comparison to controls using functional magnetic resonance imaging (fMRI) and to investigate whether modulations in jaw clenching led to different pain reports and/or changes in neural activity in motor and pain processing areas within and between both groups.

Methods: A total of 40 participants (21 patients with bruxism and TMD-related pain and 19 healthy controls) performed a tooth-clenching task while lying inside a 3T MRI scanner. Participants were instructed to mildly or strongly clench their teeth for brief periods of 12 seconds and to subsequently rate their clenching intensity and pain experience after each clenching period.

Results: Patients reported significantly more pain during strong clenching compared to mild clenching. Further results showed significant differences between patients and controls in activity in areas of brain networks commonly associated with pain processing, which were also correlated with reported pain intensity. There was no evidence for differences in activity in motor-related areas between groups, which contrasts with findings of previous research.

Conclusions: Brain activity in patients with bruxism and TMD-related pain is correlated more with pain processing than with motoric differences.

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磨牙和颞下颌疾病相关疼痛患者咬牙紧咬的神经相关因素。

目的:利用功能磁共振成像(fMRI)测量磨牙症和颞下颌紊乱(TMD)相关疼痛患者的大脑活动，并与对照组进行比较，研究握紧下颌的调节是否会导致两组内部和之间不同的疼痛报告和/或运动和疼痛处理区神经活动的变化。方法:共有40名参与者(21名磨牙和tmd相关疼痛患者和19名健康对照)躺在3T MRI扫描仪内进行咬牙任务。参与者被要求在短时间内轻微或强烈地咬牙12秒，然后在每次咬牙后评估他们的咬牙强度和疼痛体验。结果:与轻度握紧相比，患者报告强烈握紧时疼痛明显增加。进一步的结果显示，患者和对照组在通常与疼痛处理相关的大脑网络区域的活动上存在显著差异，这些区域也与报告的疼痛强度相关。没有证据表明两组之间运动相关区域的活动存在差异，这与之前的研究结果形成了对比。结论:磨牙和tmd相关疼痛患者的脑活动与疼痛加工的相关性大于与运动差异的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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