Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI:10.1177/15333175221111658

Ginny Natale, Yun Zhang, Douglas William Hanes, Sean Ap Clouston

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Abstract

Objective: We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia.

Methods: We analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight. Multi-state survival models (MSMs) examined misclassification probability, time-to-event ratios, and cognitive decline.

Results: Participants (n = 6078) were 77 years old, 62% had overweight and/or obese BMI. After adjusting for the effects of cardiometabolic factors, age, sex, and race, obesity was protective against developing dementia (aHR=.44; 95%CI [.29-.67]) and dementia-related mortality (aHR=.63; 95%CI [.42-.95]).

Discussion: We found a negative relationship between obesity and dementia and dementia-related mortality, a finding that has been underreported in the literature. The continuing obesity epidemic might complicate the diagnosis and treatment of dementia.

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晚年肥胖是预防痴呆和痴呆相关死亡率的一个保护因素。

目的：我们估计了体重不足、正常、超重和肥胖的老年人从认知正常到轻度认知障碍（MCI）到可能的痴呆和死亡的转变，其中检查的时间与痴呆的严重程度有关。方法：我们分析了国民健康和老龄化趋势研究（NHATS）的六波。根据身高和体重计算体重指数。多状态生存模型（MSM）检查了错误分类概率、时间与事件比率和认知能力下降。结果：参与者（n=6078）年龄77岁，62%的人有超重和/或肥胖的BMI。在调整了心脏代谢因素、年龄、性别和种族的影响后，肥胖对发展为痴呆症（aHR=0.44；95%CI[.29-.67]）和痴呆症相关死亡率（aHR=.63；95%CI[.42-.95]）具有保护作用。肥胖的持续流行可能会使痴呆症的诊断和治疗复杂化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).