New developments in the biology of fibroblast growth factors.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2022-07-01 DOI:10.1002/wsbm.1549
David M Ornitz, Nobuyuki Itoh
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引用次数: 42

Abstract

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine kinases (FGFRs 1-4) and four intracellular proteins (intracellular FGFs or iFGFs) that primarily function to regulate the activity of voltage-gated sodium channels and other molecules. The canonical FGFs, endocrine FGFs, and iFGFs have been reviewed extensively by us and others. In this review, we briefly summarize past reviews and then focus on new developments in the FGF field since our last review in 2015. Some of the highlights in the past 6 years include the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, an expanded understanding of endocrine FGF signaling, functions for FGF signaling in stem cell pluripotency and differentiation, roles for FGF signaling in tissue homeostasis and regeneration, a continuing elaboration of mechanisms of FGF signaling in development, and an expanding appreciation of roles for FGF signaling in neuropsychiatric diseases. This article is categorized under: Cardiovascular Diseases > Molecular and Cellular Physiology Neurological Diseases > Molecular and Cellular Physiology Congenital Diseases > Stem Cells and Development Cancer > Stem Cells and Development.

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成纤维细胞生长因子生物学的新进展。
成纤维细胞生长因子(FGF)家族由18种分泌信号蛋白组成,包括典型FGFs和内分泌FGFs,可激活四种受体酪氨酸激酶(fgfr 1-4)和四种细胞内蛋白(细胞内FGFs或iFGFs),其主要功能是调节电压门控钠通道和其他分子的活性。我们和其他人已经对典型FGFs、内分泌FGFs和ifgf进行了广泛的综述。在这篇综述中,我们简要总结了过去的综述,然后重点介绍了自2015年上次综述以来FGF领域的新进展。过去6年的一些亮点包括使用光遗传学工具、病毒载体和诱导转基因来实验调节FGF信号、小分子FGFR抑制剂的临床应用、对内分泌FGF信号的进一步了解、FGF信号在干细胞多能性和分化中的功能、FGF信号在组织稳态和再生中的作用、FGF信号在发育中的机制的持续阐述。以及对FGF信号在神经精神疾病中的作用的进一步认识。本文分类如下:心血管疾病>分子与细胞生理神经疾病>分子与细胞生理先天性疾病>干细胞与发育癌症>干细胞与发育
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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