Seroprevalence of Herpes Simplex Viruses Types 1 and 2 in a Population, Age 15-35 Years, of Mashhad City.

Q2 Biochemistry, Genetics and Molecular Biology Iranian Biomedical Journal Pub Date : 2023-03-01 DOI:10.61186/ibj.3828

Ahmad Taherpoor, Arastoo Vojdani, Seyed Mohamad Ali Hashemi, Arian Amali, Mohammad Reza Mardani, Majid Ghayour Mobarhan, Habibollah Esmaily, Mohammad Taghi Shakeri, Mansoureh Bakhshi, Mojtaba Meshkat, Amin Hooshyar Chechaklou, Samaneh Abolbashari, Aida Gholoobi, Zahra Meshkat

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Abstract

Background: Considering the high prevalence and clinical importance of herpes simplex virus (HSV) infection worldwide, we aimed to evaluate the seroprevalence of HSV-1 and HSV-2 in a population aged between 15 and 35 years in Mashhad, Iran.

Methods: This cross-sectional study was conducted on 916 cases composed of 288 (31.4%) men and 628 (68.6%) women. Using ELISA method, the presence of IgM and IgG antibodies against HSV-1 and HSV-2 was assessed.

Results: Among the population studied, 681 (74.3%) cases were positive for anti-HSV antibodies, while 235 (25.7%) cases were negative. Moreover, no IgMs were found and all positive subjects had IgG antibodies. Age (p < 0.001), occupation (p < 0.001), education (p = 0.006), smoking (p = 0.029), and BMI (p = 0.004) demonstrated a significant association with HSV-1 and HSV-2 infection.

Conclusion: Our study indicates a high seroprevalence of HSV infection; however, there was no cases positive for IgM antibodies, suggesting the high prevalence of latent infection.

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马什哈德市 15-35 岁人群中 1 型和 2 型单纯疱疹病毒的血清流行率。

背景：考虑到单纯疱疹病毒（HSV）感染在全球的高流行率和临床重要性，我们旨在评估伊朗马什哈德市 15 至 35 岁人群中 HSV-1 和 HSV-2 的血清流行率：这项横断面研究针对 916 例病例进行，其中男性 288 例（31.4%），女性 628 例（68.6%）。采用酶联免疫吸附法对 HSV-1 和 HSV-2 的 IgM 和 IgG 抗体进行了评估：结果：在所研究的人群中，681 例（74.3%）抗 HSV 抗体呈阳性，235 例（25.7%）呈阴性。此外，没有发现 IgMs，所有阳性者都有 IgG 抗体。年龄（p < 0.001）、职业（p < 0.001）、教育程度（p = 0.006）、吸烟（p = 0.029）和体重指数（p = 0.004）与 HSV-1 和 HSV-2 感染有显著相关性：我们的研究表明，HSV 感染的血清流行率很高；但是，没有 IgM 抗体阳性的病例，这表明潜伏感染的流行率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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