β-Like DNA polymerases and prospects for their use as targets in chemotherapy of tumors.

Q3 Biochemistry, Genetics and Molecular Biology Biomeditsinskaya khimiya Pub Date : 2023-06-01 DOI:10.18097/PBMC20236903145
V V Davydov, A A Bukhvostov, D A Kuznetsov
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Abstract

DNA polymerases β are enzymes that perform repair of damaged DNA. In the cells of malignant tumors, there is a change in the production and properties of these enzymes, which is accompanied by altered viability of tumor cells. Analysis of the publications available in Russian and international databases (Pubmed, Elsevier) on the structure and properties of DNA polymerases β and their role in cell growth and proliferation, published over the past 20 years, has shown overexpression of genes encoding β-like DNA polymerases in many types of malignant tumors cells. This explains the maintenance of their viability and proliferative activity. Targeted inhibition of β-like DNA polymerases is accompanied by antiproliferative and antitumor effects. Stable paramagnetic isotopes of magnesium (25Mg2+) or other divalent metals (43Ca2+ and 67Zn2+) with uncompensated nuclear spin isotopes, as well as short single-stranded polydeoxyribonucleotides, can be used as promising antitumor pharmacophores.

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β样DNA聚合酶及其作为肿瘤化疗靶点的应用前景。
DNA聚合酶β是修复受损DNA的酶。在恶性肿瘤细胞中,这些酶的产生和性质发生了变化,并伴随着肿瘤细胞生存能力的改变。对俄罗斯和国际数据库(Pubmed, Elsevier)中关于DNA聚合酶β的结构和性质及其在细胞生长和增殖中的作用的出版物进行分析,在过去20年发表的出版物中,发现在许多类型的恶性肿瘤细胞中编码β样DNA聚合酶的基因过表达。这解释了它们维持生存能力和增殖活动的原因。靶向抑制β样DNA聚合酶具有抗增殖和抗肿瘤作用。具有无补偿核自旋同位素的镁(25Mg2+)或其他二价金属(43Ca2+和67Zn2+)的稳定顺磁同位素,以及短单链多脱氧核糖核苷酸,可以作为有前途的抗肿瘤药物载体。
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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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