Acute, chronic, and post-mortem toxicity: a review focused on three different classes of new psychoactive substances.

IF 2.8 4区医学 Q2 TOXICOLOGY Forensic Toxicology Pub Date : 2023-07-01 Epub Date: 2023-01-06 DOI:10.1007/s11419-022-00657-3

Caio H P Rodrigues, Lívia S Mariotto, Jade S Castro, Paulo H Peruquetti, Newton C Silva-Junior, Aline T Bruni

{"title":"Acute, chronic, and post-mortem toxicity: a review focused on three different classes of new psychoactive substances.","authors":"Caio H P Rodrigues, Lívia S Mariotto, Jade S Castro, Paulo H Peruquetti, Newton C Silva-Junior, Aline T Bruni","doi":"10.1007/s11419-022-00657-3","DOIUrl":null,"url":null,"abstract":"Purpose: New psychoactive substances (NPS) are not controlled under the Single Convention on Narcotic Drugs of 1961 or the 1971 Convention, but they may pose a public health threat. Knowledge of the main properties and toxicological effects of these substances is lacking. According to the current Drugs Law (Law n. 11.343/2006), the Brazilian Surveillance Agency issues directives for forbidden substances in Brazil, and structural classes of synthetic cannabinoids, cathinones, and phenylethylamines are considered illicit drugs. Considering that data on these controlled substances are scattered, the main objective of this work was to collect and organize data to generate relevant information on the toxicological properties of NPS.Methods: We carried out a literature review collecting information on the acute, chronic, and post-mortem toxicity of these classes of NSP. We searched info in five scientific databases considering works from 2017 to 2021 and performed a statistical evaluation of the data.Results: Results have shown a general lack of studies in this field given that many NPS have not had their toxicity evaluated. We observed a significant difference in the volume of data concerning acute and chronic/post-mortem toxicity. Moreover, studies on the adverse effects of polydrug use are scarce.Conclusions: More in-depth information about the main threats involving NPS use are needed.","PeriodicalId":12329,"journal":{"name":"Forensic Toxicology","volume":"41 2","pages":"187-212"},"PeriodicalIF":2.8000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forensic Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11419-022-00657-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: New psychoactive substances (NPS) are not controlled under the Single Convention on Narcotic Drugs of 1961 or the 1971 Convention, but they may pose a public health threat. Knowledge of the main properties and toxicological effects of these substances is lacking. According to the current Drugs Law (Law n. 11.343/2006), the Brazilian Surveillance Agency issues directives for forbidden substances in Brazil, and structural classes of synthetic cannabinoids, cathinones, and phenylethylamines are considered illicit drugs. Considering that data on these controlled substances are scattered, the main objective of this work was to collect and organize data to generate relevant information on the toxicological properties of NPS.

Methods: We carried out a literature review collecting information on the acute, chronic, and post-mortem toxicity of these classes of NSP. We searched info in five scientific databases considering works from 2017 to 2021 and performed a statistical evaluation of the data.

Results: Results have shown a general lack of studies in this field given that many NPS have not had their toxicity evaluated. We observed a significant difference in the volume of data concerning acute and chronic/post-mortem toxicity. Moreover, studies on the adverse effects of polydrug use are scarce.

Conclusions: More in-depth information about the main threats involving NPS use are needed.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

急性、慢性和死后毒性：以三类不同的新型精神活性物质为重点的综述。

目的：新精神活性物质（NPS）不受 1961 年《麻醉品单一公约》或 1971 年《公约》的管制，但可能对公众健康构成威胁。人们对这些物质的主要特性和毒理作用缺乏了解。根据现行的《毒品法》（第 11.343/2006 号法律），巴西监督局发布了关于巴西禁用物质的指令，合成大麻素、卡西酮和苯乙胺等结构类物质被视为非法药物。考虑到有关这些受管制物质的数据比较零散，这项工作的主要目的是收集和整理数据，以生成有关 NPS 毒理学特性的相关信息：方法：我们进行了一次文献综述，收集了有关这几类 NSP 的急性、慢性和死后毒性的信息。我们在五个科学数据库中搜索了 2017 年至 2021 年的作品信息，并对数据进行了统计评估：结果表明，鉴于许多非杀伤人员地雷的毒性尚未得到评估，该领域的研究普遍缺乏。我们观察到，有关急性毒性和慢性/死后毒性的数据量存在明显差异。此外，关于使用多种药物的不良影响的研究也很少：结论：需要更深入地了解使用非兴奋剂的主要威胁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Forensic Toxicology TOXICOLOGY-

CiteScore

5.80

自引率

9.10%

发文量

审稿时长

3 months

期刊介绍： The journal Forensic Toxicology provides an international forum for publication of studies on toxic substances, drugs of abuse, doping agents, chemical warfare agents, and their metabolisms and analyses, which are related to laws and ethics. It includes original articles, reviews, mini-reviews, short communications, and case reports. Although a major focus of the journal is on the development or improvement of analytical methods for the above-mentioned chemicals in human matrices, appropriate studies with animal experiments are also published. Forensic Toxicology is the official publication of the Japanese Association of Forensic Toxicology (JAFT) and is the continuation of the Japanese Journal of Forensic Toxicology (ISSN 0915-9606).