Comparison of computed tomography response criteria after chemoembolization of hepatic carcinoma in dogs.

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2023-01-01
Cleo Rogatko, Chick Weisse, Tobias Schwarz, Allyson Berent, Marcio Diniz
{"title":"Comparison of computed tomography response criteria after chemoembolization of hepatic carcinoma in dogs.","authors":"Cleo Rogatko,&nbsp;Chick Weisse,&nbsp;Tobias Schwarz,&nbsp;Allyson Berent,&nbsp;Marcio Diniz","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The objective of this study was to evaluate unidimensional (mm), bidimensional (mm<sup>2</sup>), or tridimensional (mL) computed tomography (CT) tumor measurements for ability to discriminate changes in lesion size and predict survival in dogs with nonresectable hepatic carcinoma treated with drug-eluting bead transarterial-chemoembolization (DEB-TACE) and to compare CT response <i>via</i> Response Evaluation Criteria in Solid Tumors 1.1 (mm), World Health Organization (mm<sup>2</sup>), ellipsoid and spherical volume (mL), and percent necrosis, for their ability to differentiate treatment responders. This was a prospective, single-arm clinical trial. DEB-TACE was performed to varying levels of blood flow stasis in 16 client-owned dogs with nonresectable hepatic carcinoma. Computed tomography imaging responses were assessed and compared to median survival time. Results revealed that initial, follow-up, or changes in unidimensional, bidimensional, or tridimensional tumor measurements were not associated with survival. Larger bidimensional and tridimensional tumor measurements/body weight on initial and follow-up CT were significantly associated with a shorter median survival time [bidimensional (<i>P</i> = 0.04, 0.016) and tridimensional (<i>P</i> = 0.025, 0.015), respectively]. A higher percent necrosis on initial CT was significantly associated with a shorter median survival time (<i>P</i> = 0.038). Ellipsoid volumetric criteria detected treatment response most frequently; however, response classification was not associated with median survival time. Computed tomography bidimensional and tridimensional tumor measurements/body weight before and after DEB-TACE may help to predict median survival time for dogs undergoing DEB-TACE for hepatic carcinoma.</p>","PeriodicalId":9550,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"87 1","pages":"74-81"},"PeriodicalIF":1.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808882/pdf/cjvr_01_74.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","FirstCategoryId":"97","ListUrlMain":"","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Veterinary","Score":null,"Total":0}
引用次数: 0

Abstract

The objective of this study was to evaluate unidimensional (mm), bidimensional (mm2), or tridimensional (mL) computed tomography (CT) tumor measurements for ability to discriminate changes in lesion size and predict survival in dogs with nonresectable hepatic carcinoma treated with drug-eluting bead transarterial-chemoembolization (DEB-TACE) and to compare CT response via Response Evaluation Criteria in Solid Tumors 1.1 (mm), World Health Organization (mm2), ellipsoid and spherical volume (mL), and percent necrosis, for their ability to differentiate treatment responders. This was a prospective, single-arm clinical trial. DEB-TACE was performed to varying levels of blood flow stasis in 16 client-owned dogs with nonresectable hepatic carcinoma. Computed tomography imaging responses were assessed and compared to median survival time. Results revealed that initial, follow-up, or changes in unidimensional, bidimensional, or tridimensional tumor measurements were not associated with survival. Larger bidimensional and tridimensional tumor measurements/body weight on initial and follow-up CT were significantly associated with a shorter median survival time [bidimensional (P = 0.04, 0.016) and tridimensional (P = 0.025, 0.015), respectively]. A higher percent necrosis on initial CT was significantly associated with a shorter median survival time (P = 0.038). Ellipsoid volumetric criteria detected treatment response most frequently; however, response classification was not associated with median survival time. Computed tomography bidimensional and tridimensional tumor measurements/body weight before and after DEB-TACE may help to predict median survival time for dogs undergoing DEB-TACE for hepatic carcinoma.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
犬肝癌化疗栓塞后ct反应标准的比较。
本研究的目的是评估单维(mm)、二维(mm2)或三维(mL)计算机断层扫描(CT)肿瘤测量在鉴别病变大小变化和预测不可切除肝癌犬的生存能力方面的作用,并通过实体瘤1.1 (mm)、世界卫生组织(mm2)、椭球和球形体积(mL)的反应评价标准比较CT反应。以及坏死百分率,因为它们区分治疗反应者的能力。这是一项前瞻性单臂临床试验。对16只患有不可切除肝癌的狗进行了不同程度的血流量停滞的DEB-TACE治疗。评估计算机断层成像反应并比较中位生存时间。结果显示,初始、随访或单维、二维或三维肿瘤测量的变化与生存无关。初始和随访CT上较大的二维和三维肿瘤尺寸/体重与较短的中位生存时间显著相关[二维(P = 0.04, 0.016)和三维(P = 0.025, 0.015)]。初始CT坏死率越高,中位生存时间越短(P = 0.038)。椭球体积标准最常检测到治疗反应;然而,反应分类与中位生存时间无关。DEB-TACE前后的计算机断层扫描二维和三维肿瘤测量/体重可能有助于预测肝癌犬接受DEB-TACE的中位生存时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
期刊最新文献
Changing of the guard: Exits from and entrances to the Canadian Veterinary Medical Association Editorial Committee. Greetings from the new CJVR Editor. Iliopsoas strain demographics, concurrent injuries, and grade determined by musculoskeletal ultrasound in 72 agility dogs. Comparison of two ratios of xylazine:ketamine for the anesthesia of free-ranging North American beavers (Castor canadensis) in a remote setting. Relationship between the degree of stifle flexion and the proximal patellofemoral angle in the sagittal plane: A radiographic study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1