Comprehensive behavioral study of C57BL/6.KOR-ApoE^shl mice.

IF 1.8 4区医学 Q4 NEUROSCIENCES Translational Neuroscience Pub Date : 2023-01-01 DOI:10.1515/tnsci-2022-0284

Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

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Abstract

Background: Apolipoprotein E (ApoE) is associated with Alzheimer's disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoe^shl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoe^shl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoe^shl mice.

Results: Apoe^shl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoe^shl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test.

Conclusion: Our findings suggest the utility of Apoe^shl mice in investigating the function of ApoE in the central nervous system.

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C57BL/6的综合行为学研究KOR-ApoEshl老鼠。

背景:载脂蛋白E (ApoE)与老年阿尔茨海默病(AD)和认知功能障碍有关。对apoe缺陷小鼠(Apoeshl)的行为异常进行了广泛的研究，这种小鼠被称为AD小鼠模型。1999年发现的自发性高脂血症小鼠是由于ApoE基因突变导致的ApoE缺陷小鼠。然而，市售Apoeshl小鼠的行为异常情况尚不清楚。因此，我们旨在研究Apoeshl小鼠的行为异常。结果:Apoeshl小鼠的运动技能学习能力下降，对高度的焦虑样行为增加。Apoeshl小鼠在y迷宫、开场、明暗转换和被动回避实验中均未出现异常行为。结论:Apoeshl小鼠在研究ApoE在中枢神经系统中的功能方面具有一定的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Neuroscience NEUROSCIENCES-

CiteScore

3.00

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Translational Neuroscience provides a closer interaction between basic and clinical neuroscientists to expand understanding of brain structure, function and disease, and translate this knowledge into clinical applications and novel therapies of nervous system disorders.