Dynamic neuronal instability generates synaptic plasticity and behavior: Insights from Drosophila sleep

IF 2.4 4区 医学 Q3 NEUROSCIENCES Neuroscience Research Pub Date : 2024-01-01 DOI:10.1016/j.neures.2023.06.009
Masashi Tabuchi
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Abstract

How do neurons encode the information that underlies cognition, internal states, and behavior? This review focuses on the neural circuit mechanisms underlying sleep in Drosophila and, to illustrate the power of addressing neural coding in this system, highlights a specific circuit mediating the circadian regulation of sleep quality. This circuit exhibits circadian cycling of sleep quality, which depends solely on the pattern (not the rate) of spiking. During the night, the stability of spike waveforms enhances the reliability of spike timing in these neurons to promote sleep quality. During the day, instability of the spike waveforms leads to uncertainty of spike timing, which remarkably produces synaptic plasticity to induce arousal. Investigation of the molecular and biophysical basis of these changes was greatly facilitated by its study in Drosophila, revealing direct connections between genes, molecules, spike biophysical properties, neural codes, synaptic plasticity, and behavior. Furthermore, because these patterns of neural activity change with aging, this model system holds promise for understanding the interplay between the circadian clock, aging, and sleep quality. It is proposed here that neurophysiological investigations of the Drosophila brain present an exceptional opportunity to tackle some of the most challenging questions related to neural coding.

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动态神经元不稳定性产生突触可塑性和行为果蝇睡眠的启示
神经元如何编码支撑认知、内部状态和行为的信息?这篇综述将重点关注果蝇睡眠的神经回路机制,并着重介绍一个介导睡眠质量昼夜节律调节的特定回路,以说明在这一系统中处理神经编码的能力。该回路表现出睡眠质量的昼夜循环,这完全取决于尖峰的模式(而非速率)。在夜间,尖峰波形的稳定性增强了这些神经元尖峰计时的可靠性,从而提高了睡眠质量。在白天,尖峰波形的不稳定性会导致尖峰计时的不确定性,从而显著产生突触可塑性,诱发唤醒。在果蝇身上进行的研究极大地促进了对这些变化的分子和生物物理基础的研究,揭示了基因、分子、尖峰生物物理特性、神经密码、突触可塑性和行为之间的直接联系。此外,由于这些神经活动模式会随着衰老而改变,因此该模型系统有望理解昼夜节律、衰老和睡眠质量之间的相互作用。本文提出,果蝇大脑的神经生理学研究为解决与神经编码相关的一些最具挑战性的问题提供了一个难得的机会。
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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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