GABRP is a Promising Prognostic Biomarker and Associated with Immune Cell Infiltration in Lung Squamous Cell Carcinoma.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2023-01-01 DOI:10.2147/PGPM.S403868

Jiding Fu, Jie Lin, Xiaohui Zeng, Guanger Li, Yier Wei, Lewu Xian

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引用次数: 1

Abstract

Background: GABRP has been reported to play an oncogenic role in various carcinomas. However, no report has been found for its involvement in lung squamous cell carcinoma (LUSC) development yet. We aimed to explore the expression and prognostic roles of GABRP and assessment of its association with tumor microenvironment in LUSC.

Methods: The GABRP expression in LUSC was analyzed using TCGA, GEO, and HPA databases. The Kaplan-Meier, Cox regression analysis, and receiver operating characteristic (ROC) curve were applied to assess the prognostic and diagnostic values of GABRP in LUSC. We also performed ESTIMATE and ssGSEA to explore the association between GABRP expression and immune cell infiltrations. GABRP was highly expressed in LUSC patients, and up-regulation of GABRP was associated with shorter overall survival (OS). Cox regression analysis indicated that GABRP was an independent prognostic factor for LUSC patients. KEGG analysis revealed that GABRP may play an important role in starch and sucrose metabolism and nicotine addiction. Specifically, GABRP expression showed significant positive correlations with the infiltration levels of most types of immune cells, as well as immune checkpoint molecules expression.

Conclusion: Up-regulation of GABRP in LUSC could be severed as a prognostic marker and a potential target for immunotherapy in LUSC.

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GABRP是一种有前景的预后生物标志物，与肺鳞状细胞癌免疫细胞浸润有关。

背景:GABRP已被报道在多种癌症中起致瘤作用。然而，尚未见其参与肺鳞状细胞癌(LUSC)发展的报道。我们旨在探讨GABRP在LUSC中的表达和预后作用，并评估其与肿瘤微环境的关系。方法:采用TCGA、GEO和HPA数据库对LUSC中GABRP的表达进行分析。应用Kaplan-Meier、Cox回归分析和受试者工作特征(ROC)曲线评价GABRP对LUSC的预后和诊断价值。我们还进行了ESTIMATE和ssGSEA来探索GABRP表达与免疫细胞浸润之间的关系。GABRP在LUSC患者中高表达，GABRP上调与较短的总生存期(OS)相关。Cox回归分析显示GABRP是LUSC患者的独立预后因素。KEGG分析显示GABRP可能在淀粉和蔗糖代谢以及尼古丁成瘾中发挥重要作用。具体而言，GABRP的表达与大多数类型免疫细胞的浸润水平以及免疫检查点分子的表达呈显著正相关。结论:GABRP在LUSC中上调可作为LUSC预后指标和免疫治疗的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

3.30

自引率

5.30%

发文量

110

审稿时长

16 weeks

期刊介绍： Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.