The Cognitive Profile of Atypical Parkinsonism: A Meta-Analysis.

IF 5.4 2区心理学 Q1 NEUROSCIENCES Neuropsychology Review Pub Date : 2023-06-01 DOI:10.1007/s11065-022-09551-6

Simona Raimo, Mariachiara Gaita, Maria Cropano, Giusi Mautone, Alfonsina D'Iorio, Luigi Trojano, Gabriella Santangelo

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Abstract

Atypical Parkinsonism (AP) syndromes are characterized by a wide spectrum of non-motor symptoms including prominent attentional and executive deficits. However, the cognitive profile of AP and its differences and similarities with that of Parkinson's Disease (PD) are still a matter of debate. The present meta-analysis aimed at identifying patterns of cognitive impairment in AP by comparing global cognitive functioning, memory, executive functions, visuospatial abilities, language, non-verbal reasoning, and processing speed test performances of patients with AP relative to healthy controls and patients with PD. All investigated cognitive domains showed a substantial impairment in patients with AP compared to healthy controls. When AP syndromes were considered separately, their cognitive functioning was distributed along a continuum from Multiple Systemic Atrophy at one extreme, with the least impaired cognitive profile (similar to that observed in PD) to Progressive Supranuclear Palsy, with the greatest decline in global cognitive and executive functioning (similar to Corticobasal Syndrome). These findings indicate that widespread cognitive impairment could represent an important clinical indicator to distinguish AP from other movement disorders.

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非典型帕金森病的认知概况:一项荟萃分析。

非典型帕金森病(AP)综合征的特点是广泛的非运动症状，包括突出的注意力和执行缺陷。然而，AP的认知特征及其与帕金森病(PD)的差异和相似之处仍然存在争议。本荟萃分析旨在通过比较AP患者相对于健康对照组和PD患者的整体认知功能、记忆、执行功能、视觉空间能力、语言、非言语推理和处理速度测试表现，来确定AP认知功能障碍的模式。与健康对照组相比，所有被调查的AP患者的认知领域都显示出实质性的损害。当单独考虑AP综合征时，他们的认知功能沿一个连续体分布，从一个极端的多发性系统性萎缩，认知功能受损最少(与PD观察到的相似)到进行性核上性麻痹，整体认知和执行功能下降最大(与皮质基底综合征相似)。这些发现表明，广泛的认知障碍可能是区分AP与其他运动障碍的重要临床指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology Review 医学-神经科学

CiteScore

11.00

自引率

1.70%

发文量

期刊介绍： Neuropsychology Review is a quarterly, refereed publication devoted to integrative review papers on substantive content areas in neuropsychology, with particular focus on populations with endogenous or acquired conditions affecting brain and function and on translational research providing a mechanistic understanding of clinical problems. Publication of new data is not the purview of the journal. Articles are written by international specialists in the field, discussing such complex issues as distinctive functional features of central nervous system disease and injury; challenges in early diagnosis; the impact of genes and environment on function; risk factors for functional impairment; treatment efficacy of neuropsychological rehabilitation; the role of neuroimaging, neuroelectrophysiology, and other neurometric modalities in explicating function; clinical trial design; neuropsychological function and its substrates characteristic of normal development and aging; and neuropsychological dysfunction and its substrates in neurological, psychiatric, and medical conditions. The journal''s broad perspective is supported by an outstanding, multidisciplinary editorial review board guided by the aim to provide students and professionals, clinicians and researchers with scholarly articles that critically and objectively summarize and synthesize the strengths and weaknesses in the literature and propose novel hypotheses, methods of analysis, and links to other fields.