Inflammatory Bowel Disease Is not Linked to a Higher Rate of Adverse Events in Colonoscopy-a Nationwide Population-based Study in Sweden.

IF 8.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Journal of Crohns & Colitis Pub Date : 2023-12-30 DOI:10.1093/ecco-jcc/jjad114
Bjarki T Alexandersson, Anna Andreasson, Charlotte Hedin, Gabriella Broms, Peter T Schmidt, Anna Forsberg
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Abstract

Background and aims: Inflammatory bowel disease may cause long-standing inflammation and fibrosis and may increase the risk of adverse events in colonoscopy. We evaluated whether inflammatory bowel disease and other potential risk factors are associated with bleeding or perforation in a nationwide, population-based, Swedish study.

Methods: Data from 969 532 colonoscopies, including 164 012 [17%] on inflammatory bowel disease patients, between 2003 and 2019, were retrieved from the National Patient Registers. ICD-10 codes for bleeding [T810] and perforation [T812] within 30 days of the colonoscopy were recorded. Multivariable logistic regression was used to test if inflammatory bowel disease status, inpatient setting, time period, general anaesthesia, age, sex, endoscopic procedures, and antithrombotic treatment were associated with higher odds for bleeding and perforation.

Results: Bleeding and perforation were reported in 0.19% and 0.11% of all colonoscopies, respectively. Bleeding [odds ratio 0.66, p <0.001] and perforation [odds ratio 0.79, p <0.033] were less likely in colonoscopies in individuals with inflammatory bowel disease status. Bleeding and perforation were more common in inpatient than in outpatient inflammatory bowel disease colonoscopies. The odds for bleeding but not perforation increased between 2003 to 2019. General anaesthesia was associated with double the odds for perforation.

Conclusions: Individuals with inflammatory bowel disease did not have more adverse events compared with individuals without inflammatory bowel disease status. However, the inpatient setting was associated with more adverse events, particularly in inflammatory bowel disease status. General anaesthesia was associated with a greater risk of perforation.

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炎症性肠病与较高的结肠镜检查不良事件发生率无关--基于瑞典全国人口的研究。
背景和目的:炎症性肠病可能导致长期炎症和纤维化,并可能增加结肠镜检查中发生不良事件的风险。我们在一项全国性、基于人群的瑞典研究中评估了炎症性肠病和其他潜在风险因素是否与出血或穿孔相关:从全国患者登记册中检索了 2003 年至 2019 年期间 969 532 例结肠镜检查的数据,其中包括 164 012 例[17%]炎症性肠病患者。记录了结肠镜检查后 30 天内出血 [T810] 和穿孔 [T812] 的 ICD-10 编码。采用多变量逻辑回归来检验炎症性肠病状态、住院环境、时间段、全身麻醉、年龄、性别、内镜手术和抗血栓治疗是否与出血和穿孔的高几率有关:所有结肠镜检查中分别有 0.19% 和 0.11% 出现出血和穿孔。出血[几率比 0.66,P与没有炎症性肠病的人相比,患有炎症性肠病的人发生的不良事件并不多。然而,住院环境与更多不良事件有关,尤其是炎症性肠病患者。全身麻醉与更高的穿孔风险有关。
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来源期刊
Journal of Crohns & Colitis
Journal of Crohns & Colitis 医学-胃肠肝病学
CiteScore
15.50
自引率
7.50%
发文量
1048
审稿时长
1 months
期刊介绍: Journal of Crohns and Colitis is concerned with the dissemination of knowledge on clinical, basic science and innovative methods related to inflammatory bowel diseases. The journal publishes original articles, review papers, editorials, leading articles, viewpoints, case reports, innovative methods and letters to the editor.
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