Mortality of multiple sclerosis in Iceland population-based mortality of MS in incidence and prevalence cohorts.

Olöf Eliasdottir, Ólafur Kjartansson, Elias Olafsson
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Abstract

Introduction: Mortality is an important feature of the natural history of multiple sclerosis (MS). We report the mortality of all individuals with MS in Iceland, identified in a nationwide population-based study.

Patients and methods: The results are based on a prevalence cohort and an incidence cohort. The prevalence cohort consisted of all patients with MS (n = 526) living in Iceland on the 31 December 2007. The incidence cohort consisted of all residents of Iceland (n = 222) diagnosed with MS during 2002 to 2007. Mortality was determined by following both the incidence cohort (from diagnosis) and the prevalence cohort (from the prevalence day) until death or 31 December 2020. The mortality, associated with MS, was compared with that expected in the Icelandic population (standardized mortality ratio (SMR)).

Results: (a) Prevalence cohort (n = 526). The mean follow up was 12.0 years (range 0.3-13.0). The SMR was 1.6 (95% confidence interval (CI) 1.3-2.0). (b) Incidence cohort (n = 222). The mean follow up was 15.4 years (range 3.7-18.5). The SMR was 1.2 (95% CI 0.6-2.2).

Conclusion: During the follow-up period, there was a substantial increase in mortality among the patients with MS, compared with the general population. There was no increase in mortality among the incidence cohort, when followed for up to 18.5 years following diagnosis.

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冰岛多发性硬化症的死亡率:发病率和患病率队列中基于人群的MS死亡率。
死亡率是多发性硬化症(MS)自然史的一个重要特征。我们报告了冰岛所有MS患者的死亡率,这是在一项全国性的基于人群的研究中确定的。患者和方法:研究结果基于患病率队列和发病率队列。患病率队列包括2007年12月31日居住在冰岛的所有MS患者(n = 526)。发病率队列包括2002年至2007年间诊断为多发性硬化症的所有冰岛居民(n = 222)。通过跟踪发病率队列(自诊断起)和患病率队列(自患病率日起)直至死亡或2020年12月31日,确定死亡率。将与多发性硬化症相关的死亡率与冰岛人口的预期死亡率(标准化死亡率(SMR))进行比较。结果:(a)患病率队列(n = 526)。平均随访时间为12.0年(0.3-13.0年)。SMR为1.6(95%置信区间(CI) 1.3 ~ 2.0)。(b)发病率队列(n = 222)。平均随访时间为15.4年(3.7-18.5年)。SMR为1.2 (95% CI 0.6-2.2)。结论:在随访期间,MS患者的死亡率与一般人群相比有明显增加。在确诊后18.5年的随访中,发病率队列的死亡率没有增加。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
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