Exercise effects on motor function, manual dexterity, and brain oscillatory activity in individuals with Parkinson's disease: Randomized controlled trial protocol.

IF 1.5 Q3 REHABILITATION Physiotherapy Research International Pub Date : 2023-10-01 Epub Date: 2023-05-04 DOI:10.1002/pri.2009
Maryela de Oliveira Menacho, Kevin Pacheco-Barrios, Augusto J Mendes, Tatiana de Oliveira Sato, Felipe Fregni, Anna Carolyna Lepesteur Gianlorenço
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Abstract

Background: Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder. Exercise protocols are promising interventions to improve PD symptoms, however, the best modality and its neural correlates are still unknown.

Objectives: To evaluate the effects of the aerobic, strength and task-oriented upper-limb exercises in motor function, manual dexterity, and brain oscillations of individuals with PD.

Method: In this clinical trial, 44 PD patients aged 40-80 years will be randomized in four groups: aerobic training (AT), strength training (ST), task-oriented training (TOT), and waiting list group (CG). The AT group will perform 30 min of a cycle ergometer on 50%-70% of the reserve heart rate. The ST group will use equipment for upper limb muscles and will perform two series of 8-12 repetitions for each exercise, and intensity between 50% and 70% of one maximum repetition will be used. The TOT group will perform a program consisting of three activities to enhance reaching, grasping, and manipulation. All the groups will perform three sessions per week for 8 weeks. We will use the UPDRS Motor function section, Nine-Hole Peg Test, and quantitative electroencephalography to measure motor function, manual dexterity, and brain oscillations, respectively. ANOVA and regression models will be used to compare outcomes within and between groups.

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运动对帕金森病患者运动功能、手巧和大脑振荡活动的影响:随机对照试验方案。
背景:帕金森病(PD)是第二常见的进行性神经退行性疾病。运动方案是改善帕金森病症状的有希望的干预措施,然而,最佳方式及其神经相关性仍然未知。目的:评价有氧、力量和任务导向上肢训练对帕金森病患者运动功能、手巧和大脑振荡的影响。方法:在本临床试验中,44名40-80岁的帕金森病患者将被随机分为四组:有氧训练(AT)、力量训练(ST)、任务导向训练(TOT)和等待名单组(CG)。AT组将在储备心率的50%-70%下进行30分钟的循环测力计。ST组将使用上肢肌肉设备,每次锻炼将进行两系列8-12次重复,强度在一次最大重复的50%至70%之间。TOT小组将执行一个由三项活动组成的程序,以增强伸手、抓握和操纵能力。所有小组将在8周内每周进行三次训练。我们将使用UPDRS运动功能部分、九孔钉测试和定量脑电图分别测量运动功能、手巧和大脑振荡。方差分析和回归模型将用于比较组内和组间的结果。
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来源期刊
CiteScore
3.30
自引率
5.90%
发文量
53
期刊介绍: Physiotherapy Research International is an international peer reviewed journal dedicated to the exchange of knowledge that is directly relevant to specialist areas of physiotherapy theory, practice, and research. Our aim is to promote a high level of scholarship and build on the current evidence base to inform the advancement of the physiotherapy profession. We publish original research on a wide range of topics e.g. Primary research testing new physiotherapy treatments; methodological research; measurement and outcome research and qualitative research of interest to researchers, clinicians and educators. Further, we aim to publish high quality papers that represent the range of cultures and settings where physiotherapy services are delivered. We attract a wide readership from physiotherapists and others working in diverse clinical and academic settings. We aim to promote an international debate amongst the profession about current best evidence based practice. Papers are directed primarily towards the physiotherapy profession, but can be relevant to a wide range of professional groups. The growth of interdisciplinary research is also key to our aims and scope, and we encourage relevant submissions from other professional groups. The journal actively encourages submissions which utilise a breadth of different methodologies and research designs to facilitate addressing key questions related to the physiotherapy practice. PRI seeks to encourage good quality topical debates on a range of relevant issues and promote critical reflection on decision making and implementation of physiotherapy interventions.
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