The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2023-06-20 Epub Date: 2023-03-31 DOI:10.1146/annurev-biochem-052521-040313
Christian Siebold, Rajat Rohatgi
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引用次数: 0

Abstract

Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate tissue development in metazoans. A remarkable feature of HH signaling is the repeated use of cholesterol in steps spanning ligand biogenesis, secretion, dispersal, and reception on target cells. A cholesterol molecule covalently attached to HH ligands is used as a molecular baton by transfer proteins to guide their secretion, spread, and reception. On target cells, a signaling circuit composed of a cholesterol transporter and sensor regulates transmission of HH signals across the plasma membrane to the cytoplasm. The repeated use of cholesterol in signaling supports the view that the HH pathway likely evolved by coopting ancient systems to regulate the abundance or organization of sterol-like lipids in membranes.

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胆固醇与刺猬信号之间密不可分的关系
刺猬(HH)通路的配体是一种旁分泌信号分子,可协调类脊椎动物的组织发育。HH 信号传导的一个显著特点是在配体的生物生成、分泌、散布和靶细胞接收等步骤中反复使用胆固醇。共价连接到 HH 配体上的胆固醇分子被转移蛋白用作分子指挥棒,引导配体的分泌、扩散和接收。在靶细胞上,由胆固醇转运体和传感器组成的信号回路调节 HH 信号穿过质膜向细胞质的传递。胆固醇在信号传递中的反复使用支持了这样一种观点,即 HH 通路很可能是通过共用古代系统来调节膜中类固醇脂质的丰度或组织而进化而来的。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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