Urocortin 2 - a protective effect in hypertension?

IF 2 4区 医学 Q3 PHYSIOLOGY Journal of Physiology and Pharmacology Pub Date : 2023-02-01 DOI:10.26402/jpp.2023.1.01
A Dzieza-Grudnik, O Siga, J Walczewska, B Wizner, P P Wolkow, F H Messerli, T Grodzicki
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Abstract

Urocortin 2, an endogenous selective ligand for the corticotropin-releasing hormone receptor type 2, has been suggested to exert cardioprotective effects. We analyzed the possible relationship between the level of Ucn2 and specific indicators of cardiovascular risk factors in patients with untreated hypertension and in healthy subjects. Sixty seven subjects were recruited: 38 with newly diagnosed treatment-naive hypertension (with no pharmacological treatment - HT group) and 29 healthy subjects without hypertension (nHT group). We evaluated ambulatory blood pressure monitoring, Ucn2 levels and metabolic indices. Multivariable regression analyses were performed to assess the effects of gender, age, and Ucn2 levels on metabolic indices or blood pressure (BP) level. Log of Ucn2 levels were higher in healthy subjects than in hypertensive patients (2.44±0.7 versus 2.09±0.66, p<.05) and correlated inversely with 24-hour diastolic blood pressure, and both night-time systolic and diastolic blood pressure regardless of age and gender (R2=0.06; R2=0.06; R2=0.052; respectively). Furthermore, Ucn2 levels inversely correlated with cholesterol and low-density cholesterol (LDL) concentrations in healthy subjects only. Ucn2 was independently related to total cholesterol (but not to LDL) regardless of age, gender and the presence of hypertension (R2=0.18). However, we did not find any relationship between urocortin 2, body mass index or waist-hip ratio as well as parameters of glucose metabolism. Our data indicates that higher levels of urocortin 2 are related to more favorable lipid profiles and lower blood pressure.

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尿皮质素2 -对高血压有保护作用?
尿皮质素2是促肾上腺皮质激素释放激素受体2型的内源性选择性配体,已被认为具有心脏保护作用。我们分析了未经治疗的高血压患者和健康受试者中Ucn2水平与心血管危险因素特定指标之间可能存在的关系。共招募了67名受试者:38名新诊断为初治高血压(未进行药物治疗- HT组),29名健康无高血压(nHT组)。我们评估了动态血压监测、Ucn2水平和代谢指标。采用多变量回归分析评估性别、年龄和Ucn2水平对代谢指标或血压水平的影响。健康人Ucn2水平的Log高于高血压患者(2.44±0.7 vs 2.09±0.66,p
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来源期刊
CiteScore
4.00
自引率
22.70%
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0
审稿时长
6-12 weeks
期刊介绍: Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.
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