The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-03-24 DOI:10.1007/s12272-023-01445-2
Jianhong Liu, Ming Zhang, Dan Deng, Xiao Zhu
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引用次数: 2

Abstract

Metformin has been used clinically for more than 60 years. As time goes by, more and more miraculous effects of metformin beyond the clinic have been discovered and discussed. In addition to the clinically approved hypoglycemic effect, it also has a positive metabolic regulation effect on the human body that cannot be ignored. Such as anti-cancer, anti-aging, brain repair, cardiovascular protection, gastrointestinal regulation, hair growth and inhibition of thyroid nodules, and other nonclinical effects. Metformin affects almost the entire body in the situation taking it over a long period, and the preventive effects of metformin in addition to treating diabetes are also beginning to be recommended in some guidelines. This review is mainly composed of four parts: the development history of metformin, the progress of clinical efficacy, the nonclinical efficacy of metformin, and the consideration and prospect of its application.

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二甲双胍的作用、作用机制及临床应用:潜力药物,潜力无限
二甲双胍在临床上已经使用了60多年。随着时间的推移,越来越多的二甲双胍在临床之外的奇效被发现和讨论。除了临床认可的降糖作用外,它对人体还有不可忽视的正向代谢调节作用。如抗癌、抗衰老、脑修复、心血管保护、胃肠调节、毛发生长和抑制甲状腺结节等非临床作用。在长期服用二甲双胍的情况下,二甲双胍几乎影响到整个身体,并且除了治疗糖尿病外,二甲双胍的预防作用也开始在一些指南中被推荐。本文主要由四部分组成:二甲双胍的发展历史、临床疗效进展、二甲双胍的非临床疗效、二甲双胍应用的思考与展望。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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