Athina-Maria Aloizou, Adnan Labedi, Daniel Richter, Ulas Ceylan, Christoph Schroeder, Carsten Lukas, Ralf Gold, Christos Krogias
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引用次数: 0
Abstract
We present a case of a 67-year-old female patient, who presented with acute cortical blindness five days after a successful resuscitation from cardiac arrest. The magnetic resonance tomography revealed a mild FLAIR signal increase of the bilateral occipital cortex. A lumbar puncture revealed considerably elevated tau protein levels, in the presence of normal phospho-tau, as a marker of brain injury, whilst neuron-specific enolase levels were normal. The diagnosis of delayed post-hypoxic encephalopathy was set. We hereby describe a rare clinical manifestation after initially successful resuscitation and encourage the studying of tau protein as a potential marker of this disease entity.
我们报告了一例 67 岁女性患者的病例,她在心脏骤停抢救成功五天后出现急性皮层失明。磁共振断层扫描显示双侧枕叶皮层的 FLAIR 信号轻度增高。腰椎穿刺显示,作为脑损伤标志的 tau 蛋白水平显著升高,而磷酸化 tau 正常,神经元特异性烯醇化酶水平正常。诊断确定为延迟性缺氧后脑病。我们在此描述了最初成功复苏后的一种罕见临床表现,并鼓励将 tau 蛋白作为这种疾病的潜在标志物进行研究。
期刊介绍:
The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.