RNA-binding proteins in autoimmunity: From genetics to molecular biology.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-07-01 Epub Date: 2023-01-19 DOI:10.1002/wrna.1772
Valeria Lodde, Matteo Floris, Enrico Zoroddu, Ignazio Roberto Zarbo, Maria Laura Idda
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Abstract

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune tolerance to the body's own cells and tissues. There is growing recognition that RNA-binding proteins (RBPs) critically govern immunity in healthy and pathological conditions by modulating gene expression post-transcriptionally at all levels: nuclear mRNA splicing and modification, export to the cytoplasm, as well as cytoplasmic mRNA transport, storage, editing, stability, and translation. Despite enormous efforts to identify new therapies for ADs, definitive solutions are not yet available in many instances. Recognizing that many ADs have a strong genetic component, we have explored connections between the molecular biology and the genetics of RBPs in ADs. Here, we review the genetics and molecular biology of RBPs in four major ADs, multiple sclerosis (MS), type 1 diabetes mellitus (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). We anticipate that gaining insights into the genetics and biology of ADs can facilitate the discovery of new therapies. This article is categorized under: RNA in Disease and Development > RNA in Disease.

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自身免疫中的 RNA 结合蛋白:从遗传学到分子生物学
自身免疫性疾病(ADs)是由于机体对自身细胞和组织失去免疫耐受而导致的慢性病变。越来越多的人认识到,RNA 结合蛋白(RBPs)通过在转录后各级调节基因表达:核 mRNA 剪接和修饰、向细胞质输出以及细胞质 mRNA 运输、储存、编辑、稳定性和翻译,对健康和病理状态下的免疫起着至关重要的作用。尽管人们为找到治疗注意力缺失症的新疗法付出了巨大努力,但在许多情况下,仍无法找到确切的解决方案。我们认识到许多注意力缺失症都有很强的遗传因素,因此我们探索了注意力缺失症中 RBPs 分子生物学和遗传学之间的联系。在此,我们回顾了四种主要注意力缺失症、多发性硬化症(MS)、1 型糖尿病(T1D)、系统性红斑狼疮(SLE)和类风湿性关节炎(RA)中 RBPs 的遗传学和分子生物学。我们预计,深入了解注意力缺失症的遗传学和生物学特性将有助于发现新的疗法。本文归类于疾病与发育中的 RNA > 疾病中的 RNA。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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