ROCK (RhoA/Rho Kinase) Activation in Atrial Fibrillation: Molecular Pathways and Clinical Implications.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2023-01-01 DOI:10.2174/1573403X19666221117092951
Riccardo Proietti, Andrea S Giordani, Calò A Lorenzo
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Abstract

Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and oxidative stress play a major role, both triggered by inflammatory processes. The additional basic event taking place in AF is atrial fibrotic remodeling, again triggered by oxidative stress, which is determined by connexins rearrangement and differentiation of fibroblasts into active collagensecreting myofibroblasts. RhoA/ROCK system is the final pathway of a wide spectrum of molecular effectors such as Angiotensin II, platelet-derived growth factor, connective tissue growth factor and transforming growth factor β, that overall determine calcium dysregulation and pro-fibrotic remodeling. Both in experimental and clinical studies, RhoA/ROCK activation has been linked to superoxide ion production, fibrotic remodeling and connexins rearrangement, with important consequences for AF pathogenesis. ROCK pathway inhibition may therefore be a therapeutic or preventive target for special AF subgroups of patients.

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心房颤动中的ROCK(RhoA/Rho激酶)激活:分子途径和临床意义。
在房颤发病机制的复杂机制中,细胞内钙超载和氧化应激起着重要作用,两者都是由炎症过程引发的。房颤中发生的另一个基本事件是心房纤维化重塑,再次由氧化应激触发,氧化应激由连接蛋白重排和成纤维细胞分化为活性胶原混凝土肌成纤维细胞决定。RhoA/ROCK系统是血管紧张素II、血小板衍生生长因子、结缔组织生长因子和转化生长因子β等广泛分子效应物的最终途径,这些效应物总体上决定了钙失调和促纤维化重塑。在实验和临床研究中,RhoA/ROCK的激活与超氧化物离子的产生、纤维化重塑和连接蛋白重排有关,对AF的发病机制具有重要影响。因此,ROCK通路抑制可能是特殊AF亚组患者的治疗或预防靶点。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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