Introversion and Neuroticism in Akinetic-Rigid Parkinson's Disease: Association With Frontal-Executive Dysfunction.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2023-01-01 DOI:10.1176/appi.neuropsych.20220115

Natascia De Lucia, Anna De Rosa, Sandra Perillo, Raffaele Sperandeo, Giuseppe De Michele, Nelson Mauro Maldonato

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Abstract

Objective: Personality changes have often been reported among people with Parkinson's disease (PD); however, no studies have investigated the associations between personality traits, cognitive function, and specific motor symptoms. In this study, the investigators assessed whether particular personality traits were associated with specific motor subtypes of PD (e.g., tremor-dominant and akinetic-rigid phenotypes) and whether frontal-executive functions were associated with personality traits among patients with a specific motor phenotype.

Methods: Forty-one people with PD and 40 healthy control participants were enrolled in the study. All participants underwent assessments of cognitive and psychological function and personality traits. The study was conducted in Italy.

Results: Tremor-dominant symptoms occurred among 20 (48.8%) people with PD, whereas 21 (51.2%) patients exhibited akinetic-rigid symptoms. Multivariate analyses of variance revealed that participants with akinetic-rigid PD demonstrated significantly poorer performance on frontal-executive tests compared with those with tremor-dominant PD. Moreover, those with akinetic-rigid PD exhibited more psychopathological symptoms and higher neuroticism and introversion compared with those with tremor-dominant PD. Correlations revealed that among participants with akinetic-rigid PD, psychopathological symptoms and neuroticism and introversion personality traits were associated with frontal-executive dysfunction, whereas among those with tremor-dominant PD, no significant associations were found between personality traits and cognitive abilities.

Conclusions: These findings suggest that specific personality and frontal-executive profiles are associated with the akinetic-rigid motor subtype of PD, thus helping to refine the different clinical manifestations of PD. A better understanding of the psychological, personality, and cognitive mechanisms in PD could also help to develop more targeted treatments.

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运动刚性帕金森病的内向和神经质:与额叶-执行功能障碍的关系。

目的:帕金森病(PD)患者经常出现人格改变的报道;然而，没有研究调查人格特征、认知功能和特定运动症状之间的关系。在这项研究中，研究人员评估了特定的人格特征是否与PD的特定运动亚型相关(例如，震颤显性和运动刚性表型)，以及前额执行功能是否与特定运动表型患者的人格特征相关。方法:41名帕金森病患者和40名健康对照者参与研究。所有参与者都接受了认知、心理功能和人格特征的评估。这项研究在意大利进行。结果:20例(48.8%)PD患者出现震颤为主症状，21例(51.2%)PD患者表现为动性僵硬症状。多变量方差分析显示，与震颤型PD患者相比，动力刚性PD患者在额执行测试中的表现明显较差。此外，与震颤型PD患者相比，运动刚性PD患者表现出更多的精神病理症状和更高的神经质和内向。结果表明，在运动刚性PD患者中，精神病理症状和神经质、内向型人格特征与额叶执行功能障碍相关，而在震颤型PD患者中，人格特征与认知能力无显著相关性。结论:这些研究结果表明，特定的人格和额-执行特征与PD的动-刚性运动亚型有关，从而有助于完善PD的不同临床表现。更好地了解PD的心理、人格和认知机制也有助于开发更有针对性的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropsychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

5.30

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.