Antimicrobial Susceptibility Distributions of Clinical Isolates of Nontuberculous Mycobacteria in Israel.

IF 2.3 4区 医学 Q3 INFECTIOUS DISEASES Microbial drug resistance Pub Date : 2023-07-01 DOI:10.1089/mdr.2023.0024
Yizhak Hershko, Amos Adler
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Abstract

There is a scarcity of data regarding the antimicrobial susceptibility testing profiles of nontuberculous mycobacterial (NTM) in Israel and other Middle Eastern countries. We aimed to describe the antimicrobial susceptibility profiles of NTM in Israel. A total of 410 clinical isolates of NTM, identified to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry or hsp65 gene sequencing, were included. Minimum inhibitory concentrations for slowly growing mycobacteria (SGM) and rapidly growing mycobacteria (RGM) for 12 and 11 drugs were determined using the Sensititre SLOMYCOI and RAPMYCOI broth microdilution plates, respectively. Mycobacterium avium complex (MAC) was the most frequently isolated species (n = 148; 36%), followed by Mycobacterium simiae (n = 93; 23%), Mycobacterium abscessus group (n = 62; 15%), Mycobacterium kansasii (n = 27; 7%), and Mycobacterium fortuitum (n = 22; 5%) accounting together for 86% of isolates. The most active agents against SGM were amikacin (98%/85%/100%) and clarithromycin (97%/99%/100%), followed by moxifloxacin (25%/10%/100%) and linezolid (3%/6%/100%) for MAC, M. simiae, and M. kansasii, respectively. For RGM, the most active agents were amikacin (98%/100%/88%) followed by linezolid (48%/80%/100%) and clarithromycin (39%/28%/94%) for M. abscessus group, M. fortuitum, and M. chelonae, respectively. These findings can assist in guiding the treatment of NTM infections.

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以色列非结核分枝杆菌临床分离株的药敏分布。
在以色列和其他中东国家,关于非结核分枝杆菌(NTM)的抗菌药物敏感性测试资料缺乏。我们的目的是描述以色列NTM的抗菌敏感性特征。采用基质辅助激光解吸电离飞行时间质谱法或hsp65基因测序技术对410株临床分离的NTM进行了种级鉴定。采用Sensititre SLOMYCOI和RAPMYCOI肉液微量稀释板分别测定12种和11种药物对慢生长分枝杆菌(SGM)和快速生长分枝杆菌(RGM)的最低抑制浓度。禽分枝杆菌复合体(MAC)是最常见的分离种(n = 148;36%),其次是类似性分枝杆菌(n = 93;23%),脓肿分枝杆菌组(n = 62;15%),堪萨斯分枝杆菌(n = 27;7%),运气分枝杆菌(n = 22;5%),占总分离株的86%。对SGM最有效的药物是阿米卡星(98%/85%/100%)和克拉霉素(97%/99%/100%),其次是莫西沙星(25%/10%/100%)和利奈唑胺(3%/6%/100%)。对于RGM,脓肿支原体组、幸运支原体组和chelonae支原体组活性最高的药物是阿米卡星(98%/100%/88%),其次是利奈唑胺(48%/80%/100%)和克拉霉素(39%/28%/94%)。这些发现有助于指导NTM感染的治疗。
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来源期刊
Microbial drug resistance
Microbial drug resistance 医学-传染病学
CiteScore
6.00
自引率
3.80%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.
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