The association between selenium and bone health: a meta-analysis.

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING Bone & Joint Research Pub Date : 2023-07-06 DOI:10.1302/2046-3758.127.BJR-2022-0420.R1
Haibin Xie, Ning Wang, Hongyi He, Zidan Yang, Jing Wu, Tuo Yang, Yilun Wang
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引用次数: 1

Abstract

Aims: Previous studies have suggested that selenium as a trace element is involved in bone health, but findings related to the specific effect of selenium on bone health remain inconclusive. Thus, we performed a meta-analysis by including all the relevant studies to elucidate the association between selenium status (dietary intake or serum selenium) and bone health indicators (bone mineral density (BMD), osteoporosis (OP), or fracture).

Methods: PubMed, Embase, and Cochrane Library were systematically searched to retrieve relevant articles published before 15 November 2022. Studies focusing on the correlation between selenium and BMD, OP, or fracture were included. Effect sizes included regression coefficient (β), weighted mean difference (WMD), and odds ratio (OR). According to heterogeneity, the fixed-effect or random-effect model was used to assess the association between selenium and bone health.

Results: From 748 non-duplicate publications, 19 studies were included. We found a significantly positive association between dietary selenium intake (β = 0.04, 95% confidence interval (CI) 0.00 to 0.07, p = 0.029) as well as serum selenium (β = 0.13, 95% CI 0.00 to 0.26, p = 0.046) and BMD. Consistently, those with higher selenium intake had a lower risk of OP (OR = 0.47, 95% CI 0.31 to 0.72, p = 0.001), and patients with OP had a significantly lower level of serum selenium than healthy controls (WMD = -2.01, 95% CI -3.91 to -0.12, p = 0.037). High dietary selenium intake was associated with a lower risk of hip fracture (OR = 0.44, 95% CI 0.37 to 0.52, p < 0.001).

Conclusion: Selenium was positively associated with BMD and inversely associated with OP; dietary selenium intake was negatively associated with hip fracture. The causality and therapeutic effect of selenium on OP needs to be investigated in future studies.

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硒与骨骼健康之间的关系:一项荟萃分析。
目的:以往的研究表明,硒作为一种微量元素与骨骼健康有关,但硒对骨骼健康的具体作用尚无定论。因此,我们进行了一项荟萃分析,包括所有相关研究,以阐明硒状态(饮食摄入或血清硒)与骨骼健康指标(骨矿物质密度(BMD)、骨质疏松症(OP)或骨折)之间的关系。方法:系统检索PubMed、Embase和Cochrane图书馆,检索2022年11月15日之前发表的相关文章。研究集中于硒与骨密度、骨密度或骨折之间的关系。效应量包括回归系数(β)、加权平均差(WMD)和优势比(OR)。根据异质性,采用固定效应或随机效应模型评估硒与骨骼健康之间的关系。结果:从748篇非重复出版物中,纳入了19篇研究。我们发现膳食硒摄入量(β = 0.04, 95%可信区间(CI) 0.00 ~ 0.07, p = 0.029)和血清硒(β = 0.13, 95% CI 0.00 ~ 0.26, p = 0.046)与骨密度呈显著正相关。一致地,硒摄入量较高的患者患OP的风险较低(OR = 0.47, 95% CI 0.31至0.72,p = 0.001), OP患者的血清硒水平显著低于健康对照组(WMD = -2.01, 95% CI -3.91至-0.12,p = 0.037)。高膳食硒摄入量与髋部骨折风险降低相关(OR = 0.44, 95% CI 0.37 ~ 0.52, p < 0.001)。结论:硒与骨密度呈正相关,与OP呈负相关;膳食硒摄入量与髋部骨折呈负相关。硒对OP的因果关系及治疗效果有待进一步研究。
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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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