Phase Delay of the 40 Hz Auditory Steady-State Response Localizes to Left Auditory Cortex in Schizophrenia.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2023-07-01 Epub Date: 2022-10-10 DOI:10.1177/15500594221130896
Brian J Roach, Yoji Hirano, Judith M Ford, Kevin M Spencer, Daniel H Mathalon
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Abstract

Background. The auditory steady state response (ASSR) is generated in bilateral auditory cortex and is the most used electroencephalographic (EEG) or magnetoencephalographic measure of gamma band abnormalities in schizophrenia. While the finding of reduced 40-Hz ASSR power and phase consistency in schizophrenia have been replicated many times, the 40-Hz ASSR phase locking angle (PLA), which assesses oscillation latency or phase delay, has rarely been examined. Furthermore, whether 40-Hz ASSR phase delay in schizophrenia is lateralized or common to left and right auditory cortical generators is unknown. Methods. Previously analyzed EEG data recorded from 24 schizophrenia patients and 24 healthy controls presented with 20-, 30-, and 40-Hz click trains to elicit ASSRs were re-analyzed to assess PLA in source space. Dipole moments in the right and left hemisphere were used to assess both frequency and hemisphere specificity of ASSR phase delay in schizophrenia. Results. Schizophrenia patients exhibited significantly reduced (ie, phase delayed) 40-Hz PLA in the left, but not the right, hemisphere, but their 20- and 30-Hz PLA values were normal. This left-lateralized 40-Hz phase delay was unrelated to symptoms or to previously reported left-lateralized PLF reductions in the schizophrenia patients. Conclusions. Consistent with sensor-based studies, the 40-Hz ASSR source-localized to left, but not right, auditory cortex was phase delayed in schizophrenia. Consistent with prior studies showing left temporal lobe volume deficits in schizophrenia, our findings suggest sluggish entrainment to 40-Hz auditory stimulation specific to left auditory cortex that are distinct from well-established deficits in gamma ASSR power and phase synchrony.

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40赫兹听觉稳态反应的相位延迟在精神分裂症患者左侧听皮层定位
背景。听觉稳态反应(ASSR)产生于双侧听觉皮层,是精神分裂症患者伽马波段异常最常用的脑电图(EEG)或脑磁图测量指标。虽然精神分裂症患者的 40-Hz ASSR 功率和相位一致性降低的发现已被多次证实,但评估振荡潜伏期或相位延迟的 40-Hz ASSR 锁相角(PLA)却很少被研究。此外,精神分裂症患者的 40-Hz ASSR 相位延迟是侧向的还是左右听觉皮层发生器共同的,目前尚不清楚。研究方法对之前分析的 24 名精神分裂症患者和 24 名健康对照者的脑电图数据进行重新分析,以评估源空间的 PLA。使用左右半球的偶极矩来评估精神分裂症患者 ASSR 相位延迟的频率和半球特异性。结果显示精神分裂症患者的左半球(而非右半球)40 Hz PLA 值明显降低(即相位延迟),但其 20 Hz 和 30 Hz PLA 值正常。这种左侧化的 40 赫兹相位延迟与精神分裂症患者的症状或之前报道的左侧化 PLF 降低无关。结论与基于传感器的研究一致,精神分裂症患者听觉皮层左侧而非右侧的40 Hz ASSR源定位存在相位延迟。我们的研究结果表明,精神分裂症患者左侧颞叶容积不足,这与之前的研究结果一致,表明左侧听觉皮层对40Hz听觉刺激的特异性伴音迟缓,有别于伽马ASSR功率和相位同步性的公认缺陷。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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