Luqi Cao, Yuhao Xie, Zhesheng Chen, Charles R Ashby
{"title":"A cycloruthenated complex, ruthenium (II) Z (RuZ) overcomes <i>in vitro</i> and <i>in vivo</i> multidrug resistance in cancer cells: A pivotal breakthrough.","authors":"Luqi Cao, Yuhao Xie, Zhesheng Chen, Charles R Ashby","doi":"10.2478/jtim-2023-0081","DOIUrl":null,"url":null,"abstract":"Multidrug resistance (MDR) is one of the major obstacles that attenuates or abrogates the efficacy of the treatment of cancer.[1] Previously, numerous studies have reported that certain metallo-complexed anticancer drugs, such as platinum (II)based compounds, are efficacious in treating specific types of cancer.[2] However, these compounds are not efficacious in MDR cancers. Consequently, there is a need for the synthesis and development of safe and efficacious metal-complexed anticancer drugs.","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 2","pages":"95-97"},"PeriodicalIF":7.4000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318915/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Translational Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/jtim-2023-0081","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Multidrug resistance (MDR) is one of the major obstacles that attenuates or abrogates the efficacy of the treatment of cancer.[1] Previously, numerous studies have reported that certain metallo-complexed anticancer drugs, such as platinum (II)based compounds, are efficacious in treating specific types of cancer.[2] However, these compounds are not efficacious in MDR cancers. Consequently, there is a need for the synthesis and development of safe and efficacious metal-complexed anticancer drugs.
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