Postoperative relative decrease in skeletal muscle mass as a predictor of quality of life in patients with gastric cancer.

IF 1.4 Q4 ONCOLOGY Molecular and clinical oncology Pub Date : 2023-08-01 DOI:10.3892/mco.2023.2655
Yoshinori Ueda, Akiyoshi Seshimo, Takahiro Okamoto
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Abstract

Low skeletal muscle mass reflects poor nutritional condition, which may impair the functional status and quality of life (QOL) of survivors of gastrectomy. The present cross-sectional study examined the association between a relative change in skeletal muscle mass and perceived postoperative health and QOL in patients with gastric cancer. The study comprised 74 patients (48 men and 26 women; median age, 68.5 years) who underwent surgery for stage I-III gastric cancer. Outcomes were measured using the Postgastrectomy Syndrome Assessment Scale-45, which was specifically developed to measure post-gastrectomy symptoms, living status, dissatisfaction with daily life and generic QOL. The skeletal muscle mass index (SMI) was estimated using computed tomography by tracing the area of the psoas major muscle to calculate the ΔSMI, defined as: (SMI before surgery-SMI at completion of the PGSAS-45 survey)/SMI before surgery x100. Associations between ΔSMI and health outcomes were assessed using univariate and multivariate analyses. The mean ΔSMI (SD) was 8.64% (10.6%). The effect size (Cohen's d) of ΔSMI <10% compared with ΔSMI ≥10% was 0.50 (95% CI: 0.02 to 0.97) for total symptom scores, -0.51 (-0.98 to -0.03) for general health, and -0.52 (-0.99 to -0.05) for the physical component summary (PCS). Multiple regression analysis showed that ΔSMI was significantly associated with PCS decline, and its standardized regression coefficient was -0.447 (-0.209 to -0.685). Determining ΔSMI may help clinicians to facilitate the objective evaluation of low skeletal mass, which reflects poor nutritional condition that can impair functional status and QOL of postoperative patients surviving gastrectomy.

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术后骨骼肌质量相对减少作为胃癌患者生活质量的预测指标。
低骨骼肌质量反映了不良的营养状况,这可能会损害胃切除术幸存者的功能状态和生活质量。本横断面研究探讨了胃癌患者骨骼肌质量的相对变化与术后健康和生活质量之间的关系。该研究包括74名患者(48名男性和26名女性;中位年龄68.5岁),因I-III期胃癌接受手术。结果采用胃切除术后综合征评估量表-45进行测量,该量表专门用于测量胃切除术后症状、生活状况、对日常生活的不满程度和一般生活质量。骨骼肌质量指数(SMI)采用计算机断层扫描,通过追踪腰肌大肌面积计算ΔSMI,定义为:(术前SMI - PGSAS-45调查完成时SMI) /术前SMI x100。使用单变量和多变量分析评估ΔSMI与健康结果之间的关联。平均值ΔSMI (SD)为8.64%(10.6%)。ΔSMI的效应量(Cohen’s d)
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