Impact of TREM1 Variants on the Risk and Prognosis of Glioma in the Chinese Han Population.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2023-01-01 DOI:10.2147/PGPM.S403870

Mingjun Hu, Jie Wei, Jie Hao, Tianbo Jin, Bin Li

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Abstract

Background: Glioma is the main pathological subtype of brain tumors with high mortality.

Objective: This study aimed to elucidate the correlation between TREM1 variants and glioma risk in the Chinese Han population.

Methods: Genotyping of six variants of TREM1 was completed by Agena MassARRAY platform in 1061 subjects (503 controls and 558 glioma patients). The relationship between TREM1 polymorphisms and glioma risk was calculated using the logistic regression model, with odds ratio (OR) and 95% confidence intervals (CIs). A multifactor dimensionality reduction (MDR) method was performed to assess SNP-SNP interactions to predict glioma risk.

Results: In this research, overall analysis illustrated an association between TREM1 rs9369269 and an increased risk of glioma. Rs9369269 was also related to the risk of glioma in patients aged ≤40 years and females. Subjects with rs9369269 AC genotype were likely to obtain glioma compared to people with CC genotype (patients with astroglioma vs healthy people). Compared to TT genotype carriers, carriers with AT genotype of rs1351835 were significantly associated with overall survival (OS).

Conclusion: Taken together, the study identified the association between TREM1 variants and glioma risk and TREM1 variants were significantly associated with the prognosis of glioma. In the future, larger samples are needed to verify the results.

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TREM1变异对中国汉族胶质瘤风险和预后的影响

背景:胶质瘤是脑肿瘤的主要病理亚型，病死率高。目的:本研究旨在阐明中国汉族人群TREM1变异与胶质瘤风险的相关性。方法:采用Agena MassARRAY平台对1061例受试者(对照组503例，胶质瘤患者558例)进行TREM1基因分型。使用logistic回归模型计算TREM1多态性与胶质瘤风险之间的关系，采用比值比(OR)和95%置信区间(ci)。采用多因素降维(MDR)方法评估SNP-SNP相互作用以预测胶质瘤风险。结果:在本研究中，总体分析表明TREM1 rs9369269与胶质瘤风险增加之间存在关联。Rs9369269也与年龄≤40岁及女性患者发生胶质瘤的风险相关。与CC基因型(星形胶质瘤患者与健康人)相比，rs9369269 AC基因型的受试者更容易罹患胶质瘤。与TT基因型携带者相比，rs1351835 AT基因型携带者与总生存期(OS)显著相关。结论:综上所述，本研究发现TREM1变异与胶质瘤风险存在相关性，TREM1变异与胶质瘤的预后显著相关。在未来，需要更大的样本来验证结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

3.30

自引率

5.30%

发文量

110

审稿时长

16 weeks

期刊介绍： Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.