Intranasal delivery of stem cells labeled by nanoparticles in neurodegenerative disorders: Challenges and opportunities.

IF 6.9 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-11-01 Epub Date: 2023-07-06 DOI:10.1002/wnan.1915
Rafieh Alizadeh, Alimohamad Asghari, Farzad Taghizadeh-Hesary, Salah Moradi, Mohammad Farhadi, Mehdi Mehdizadeh, Sara Simorgh, Alireza Nourazarian, Behrouz Shademan, Alireza Susanabadi, Kamran Kamrava
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引用次数: 1

Abstract

Neurodegenerative disorders occur through progressive loss of function or structure of neurons, with loss of sensation and cognition values. The lack of successful therapeutic approaches to solve neurologic disorders causes physical disability and paralysis and has a significant socioeconomic impact on patients. In recent years, nanocarriers and stem cells have attracted tremendous attention as a reliable approach to treating neurodegenerative disorders. In this regard, nanoparticle-based labeling combined with imaging technologies has enabled researchers to survey transplanted stem cells and fully understand their fate by monitoring their survival, migration, and differentiation. For the practical implementation of stem cell therapies in the clinical setting, it is necessary to accurately label and follow stem cells after administration. Several approaches to labeling and tracking stem cells using nanotechnology have been proposed as potential treatment strategies for neurological diseases. Considering the limitations of intravenous or direct stem cell administration, intranasal delivery of nanoparticle-labeled stem cells in neurological disorders is a new method of delivering stem cells to the central nervous system (CNS). This review describes the challenges and limitations of stem cell-based nanotechnology methods for labeling/tracking, intranasal delivery of cells, and cell fate regulation as theragnostic labeling. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.

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神经退行性疾病中纳米颗粒标记干细胞的鼻内递送:挑战和机遇。
神经退行性疾病是通过神经元功能或结构的逐渐丧失,以及感觉和认知价值的丧失而发生的。缺乏成功的治疗方法来解决神经系统疾病会导致身体残疾和瘫痪,并对患者产生重大的社会经济影响。近年来,纳米载体和干细胞作为治疗神经退行性疾病的可靠方法引起了极大的关注。在这方面,基于纳米颗粒的标记与成像技术相结合,使研究人员能够调查移植的干细胞,并通过监测其存活、迁移和分化来充分了解其命运。为了在临床环境中实际实施干细胞疗法,有必要在给药后准确标记和跟踪干细胞。已经提出了几种使用纳米技术标记和跟踪干细胞的方法,作为神经疾病的潜在治疗策略。考虑到静脉或直接给药干细胞的局限性,神经系统疾病中纳米颗粒标记的干细胞的鼻内递送是一种将干细胞递送到中枢神经系统(CNS)的新方法。这篇综述描述了基于干细胞的纳米技术方法在标记/追踪、细胞鼻内递送和细胞命运调节(作为诊断标记)方面的挑战和局限性。这篇文章分类在:治疗方法和药物发现>神经疾病的纳米医学。
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来源期刊
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
16.60
自引率
2.30%
发文量
93
期刊介绍: Nanotechnology stands as one of the pivotal scientific domains of the twenty-first century, recognized universally for its transformative potential. Within the biomedical realm, nanotechnology finds crucial applications in nanobiotechnology and nanomedicine, highlighted as one of seven emerging research areas under the NIH Roadmap for Medical Research. The advancement of this field hinges upon collaborative efforts across diverse disciplines, including clinicians, biomedical engineers, materials scientists, applied physicists, and toxicologists. Recognizing the imperative for a high-caliber interdisciplinary review platform, WIREs Nanomedicine and Nanobiotechnology emerges to fulfill this critical need. Our topical coverage spans a wide spectrum, encompassing areas such as toxicology and regulatory issues, implantable materials and surgical technologies, diagnostic tools, nanotechnology approaches to biology, therapeutic approaches and drug discovery, and biology-inspired nanomaterials. Join us in exploring the frontiers of nanotechnology and its profound impact on biomedical research and healthcare.
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