Comparison of Remineralizing Agents in the Management of White Spot Lesions In Three- to Five-year-old Children: a Clinical Trial.

IF 1.5 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pediatric dentistry Pub Date : 2023-03-15

Nambi Natchiyar, Sharath Asokan, Geetha Pr Priya, Sudhandra Viswanath

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引用次数: 0

Abstract

Purpose: The purpose of this study was to compare the effectiveness of P_11-4 self-assembling peptide (CurodontTM Repair [CR]) and fluoride varnish with xylitol-coated calcium phosphate (Embrace TM Varnish [EV]) on enamel permeability and in the management of white spot lesions (WSLs) in primary teeth.

Methods: A clinical trial was conducted among 30 children aged three to five years with WSLs in 60 anterior teeth. They were randomly assigned to receive CR or EV. Preintervention and postintervention evaluation was done by International Caries Detection and Assessment System (ICDAS) and morphometric analysis. The secondary outcome was to assess the enamel permeability using scanning electron microscopy (SEM) of polyvinyl siloxane impressions.

Results: A statistically significant reduction in the ICDAS scores (P=0.05) and percentage area of WSLs in morphometric analysis (P=0.008) was seen in the CR group after six months. No statistically significant difference was observed in the EV group after six months. The SEM evaluation did not show a significant reduction in the percentage area of droplets in both the CR and EV groups (P=0.06 and P=0.21, respectively). No significant difference was seen between EV and CR in the three parameters assessed.

Conclusion: Curodont TM Repair is effective at remineralizing white spot lesions in primary teeth and can be considered as a remineralizing agent.

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再矿化药物治疗3 - 5岁儿童白斑病变的比较:一项临床试验

目的:本研究的目的是比较P11-4自组装肽(CurodontTM Repair [CR])和木糖醇包被磷酸钙的氟化物清漆(Embrace TM varnish [EV])对乳牙牙釉质通透性和治疗白斑病变(WSLs)的效果。方法:对30例3 ~ 5岁儿童60颗前牙进行临床试验。他们被随机分配接受CR或EV治疗。采用国际龋齿检测与评估系统(ICDAS)和形态计量学分析进行干预前和干预后评价。次要结果是使用扫描电子显微镜(SEM)对聚乙烯醇硅氧烷印模评估牙釉质渗透性。结果:6个月后，CR组ICDAS评分(P=0.05)和形态计量学分析WSLs面积百分比(P=0.008)均有统计学意义降低。6个月后，EV组无统计学差异。扫描电镜分析结果显示，CR组和EV组的液滴面积百分比均未显著减少(P=0.06和P=0.21)。EV和CR在三个评估参数上无显著差异。结论:curodon TM修复剂对乳牙白斑病变有较好的再矿化效果，可作为一种再矿化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric dentistry DENTISTRY, ORAL SURGERY & MEDICINEPEDIATRI-PEDIATRICS

CiteScore

1.20

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Dentistry is the official publication of the American Academy of Pediatric Dentistry, the American Board of Pediatric Dentistry and the College of Diplomates of the American Board of Pediatric Dentistry. It is published bi-monthly and is internationally recognized as the leading journal in the area of pediatric dentistry. The journal promotes the practice, education and research specifically related to the specialty of pediatric dentistry. This peer-reviewed journal features scientific articles, case reports and abstracts of current pediatric dental research.