Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system.

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2023-01-01 DOI:10.20517/cdr.2023.16
Xiangyu Sun, Ping Zhao, Jierou Lin, Kun Chen, Jianliang Shen
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引用次数: 4

Abstract

Cancer is currently one of the most intractable diseases causing human death. Although the prognosis of tumor patients has been improved to a certain extent through various modern treatment methods, multidrug resistance (MDR) of tumor cells is still a major problem leading to clinical treatment failure. Chemotherapy resistance refers to the resistance of tumor cells and/or tissues to a drug, usually inherent or developed during treatment. Therefore, an urgent need to research the ideal drug delivery system to overcome the shortcoming of traditional chemotherapy. The rapid development of nanotechnology has brought us new enlightenments to solve this problem. The novel nanocarrier provides a considerably effective treatment to overcome the limitations of chemotherapy or other drugs resulting from systemic side effects such as resistance, high toxicity, lack of targeting, and off-target. Herein, we introduce several tumor MDR mechanisms and discuss novel nanoparticle technology applied to surmount cancer drug resistance. Nanomaterials contain liposomes, polymer conjugates, micelles, dendrimers, carbon-based, metal nanoparticles, and nucleotides which can be used to deliver chemotherapeutic drugs, photosensitizers, and small interfering RNA (siRNA). This review aims to elucidate the advantages of nanomedicine in overcoming cancer drug resistance and discuss the latest developments.

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纳米载体给药系统攻克癌症耐药途径的最新进展。
癌症是目前导致人类死亡的最棘手的疾病之一。尽管各种现代治疗手段在一定程度上改善了肿瘤患者的预后,但肿瘤细胞的多药耐药(MDR)仍然是导致临床治疗失败的主要问题。化疗耐药性是指肿瘤细胞和/或组织对药物的耐药性,通常是固有的或在治疗期间形成的。因此,迫切需要研究理想的给药系统来克服传统化疗的缺点。纳米技术的迅速发展给我们解决这一问题带来了新的启示。这种新型纳米载体提供了一种相当有效的治疗方法,克服了化疗或其他药物由于耐药、高毒性、缺乏靶向性和脱靶等全身副作用而造成的局限性。在此,我们介绍了几种肿瘤耐多药机制,并讨论了新的纳米颗粒技术应用于克服癌症耐药。纳米材料包含脂质体、聚合物偶联物、胶束、树状大分子、碳基、金属纳米颗粒和核苷酸,可用于输送化疗药物、光敏剂和小干扰RNA (siRNA)。本文旨在阐述纳米医学在克服癌症耐药方面的优势,并讨论其最新进展。
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