Environmental Influences on Risk and Disease Course in Pediatric Multiple Sclerosis

IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY Seminars in Pediatric Neurology Pub Date : 2023-07-01 DOI:10.1016/j.spen.2023.101049
Darina Dinov , James Nicholas Brenton
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Abstract

Pediatric multiple sclerosis (MS) accounts for 3%-10% of all patients diagnosed with MS. Complex interplay between environmental factors impacts the risk for MS and may also affect disease course. Many of these environmental factors are shared with adult-onset MS. However, children with MS are in closer temporal proximity to the biological onset of MS and have less confounding environmental exposures than their adult counterparts. Environmental factors that contribute to MS risk include: geographical latitude, viral exposures, obesity, vitamin deficiencies, smoking, air pollution, perinatal factors, gut microbiome, and diet. More recently, research efforts have shifted to studying the impact of these risk determinants on the clinical course of MS. In this article we will examine relevant environmental risk determinants of pediatric MS and review the current knowledge on how these factors may contribute to pediatric MS disease evolution.

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环境对儿童多发性硬化症发病风险和病程的影响
儿童多发性硬化症(MS)占所有诊断为MS的患者的3%-10%。环境因素之间的复杂相互作用影响MS的风险,也可能影响病程。这些环境因素中的许多与成人发病的多发性硬化症是共同的。然而,患有多发性痴呆症的儿童在时间上与生物发病的多发性硬化症更接近,并且与成人相比,其混杂的环境暴露更少。导致多发性硬化症风险的环境因素包括:地理纬度、病毒暴露、肥胖、维生素缺乏、吸烟、空气污染、围产期因素、肠道微生物组和饮食。最近,研究工作已转向研究这些风险决定因素对多发性硬化症临床病程的影响。在这篇文章中,我们将研究儿科多发性痴呆症的相关环境风险决定因素,并回顾目前关于这些因素如何促进儿科多发症疾病演变的知识。
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来源期刊
Seminars in Pediatric Neurology
Seminars in Pediatric Neurology CLINICAL NEUROLOGY-PEDIATRICS
CiteScore
4.80
自引率
0.00%
发文量
38
审稿时长
84 days
期刊介绍: Seminars in Pediatric Neurology is a topical journal that focuses on subjects of current importance in the field of pediatric neurology. The journal is devoted to making the status of such topics and the results of new investigations readily available to the practicing physician. Seminars in Pediatric Neurology is of special interest to pediatric neurologists, pediatric neuropathologists, behavioral pediatricians, and neurologists who treat all ages.
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