Anti-LGI1 Encephalitis Presented With Prominent Psychosis Without Loss of Consciousness.

Abstract

elevation of protein (white blood cell [WBC]: 3 mm 3 , protein: 92 mg/dL, glucose: 81 mg/dL, virus/bacteria polymerase chain reaction [PCR]: all negative). Tests for anti-LGI1 antibody in CSF and blood tests were positive. Thus, anti-LGI1 encephalitis was diagnosed. A steroid pulse therapy for 5 days was done initially. Right after steroid pulse therapy, intravenous immunoglobulin therapy for 5 days was done. At 11 days after treatment with steroid pulse and intravenous immunoglobulin therapies, the patient’s cognitive and psychiatric symptoms returned to his previous levels. In MMSE, he scored 30. No SNSB test was performed after treatment because neither the patient nor caregivers complained of any symptoms