The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2023-07-15 DOI:10.1186/s12993-023-00214-x
Yidi Chen, Jinjin Ma, Huanya Zhu, Huini Peng, Yiqun Gan
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引用次数: 1

Abstract

Background: Stressful events and meaning-making toward them play an important role in adolescents' life and growth. However, ignoring positive stressful events leads to negativity bias; further, the neural mechanisms of meaning-making are unclear. We aimed to verify the mediating role of meaning-making in stressful events and stress-related growth and the function of the default mode network (DMN) during meaning-making in this functional magnetic resonance imaging (fMRI) study.

Methods: Participants comprised 59 university students. Stressful life events, meaning-making, and stress-related growth were assessed at baseline, followed by fMRI scanning during a meaning-making task aroused by mental simulation. General linear modeling and psychophysiological interaction (PPI) analyses were used to explore the activation and functional connectivity of DMN during meaning-making.

Results: Mental simulation triggered meaning-making, and DMN activity decreased during meaning-making. Activation of the DMN was negatively correlated with coping flexibility, an indicator of stress-related growth. PPI analysis showed that meaning-making was accompanied by diminished connectivity in the DMN. DMN activation during meaning-making can mediate the relationship between positive stressful events and coping flexibility.

Conclusions: Decreased DMN activity and diminished functional connectivity in the DMN occurred during meaning-making. Activation of the DMN during meaning-making could mediate the relationship between positive stressful events and stress-related growth, which provides a cognitive neural basis for the mediating role of meaning-making in the relationship between stressful events and indicators of stress-related growth.

Implications: This study supports the idea that prosperity makes heroes, expands the meaning-making model, and suggests the inclusion of enhancing personal resources and meaning-making in education. This study was the first to validate the activation pattern and functional connectivity of the DMN during meaning-making aroused by mental simulation using an fMRI task-state examination, which can enhance our sense of meaning and provide knowledge that can be used in clinical psychology interventions.

Trial registration: The study protocol was pre-registered in Open Science Framework (see osf.io/ahm6e for details).

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心理模拟引起的意义制造过程中默认模式网络对压力相关成长的中介作用:任务功能磁共振成像研究。
背景:压力事件及其意义建构在青少年的生活和成长中起着重要的作用。然而,忽视积极的压力事件会导致消极偏见;此外,意义生成的神经机制尚不清楚。本研究旨在通过功能磁共振成像(fMRI)研究,验证意义生成在应激事件和应激相关成长中的中介作用,以及默认模式网络(DMN)在意义生成过程中的作用。方法:调查对象为59名大学生。压力生活事件、意义形成和压力相关的成长在基线时进行评估,随后在心理模拟引起的意义形成任务期间进行fMRI扫描。采用一般线性模型和心理生理相互作用(PPI)分析探讨了意义生成过程中DMN的激活和功能连通性。结果:心理模拟触发意义生成,在意义生成过程中DMN活动减弱。DMN的激活与应对灵活性呈负相关,应对灵活性是应激相关生长的一个指标。PPI分析显示,意义生成伴随着DMN连通性的减弱。意义制造过程中DMN的激活可以中介积极应激事件与应对灵活性的关系。结论:在意义形成过程中,DMN活性降低,功能连接减弱。意义制造过程中DMN的激活可以介导正向应激事件与应激相关成长之间的关系,为意义制造在应激事件与应激相关成长指标之间的中介作用提供了认知神经基础。启示:本研究支持了富裕造就英雄的观点,拓展了意义建构模型,并提出了在教育中纳入增强个人资源和意义建构的建议。本研究首次利用功能磁共振成像(fMRI)任务状态检查验证了心理模拟引起的意义制造过程中DMN的激活模式和功能连通性,这可以增强我们的意义感,并为临床心理学干预提供知识。试验注册:研究方案在开放科学框架(Open Science Framework)中预先注册。Io /ahm6e获取详细信息)。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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