Updates in histopathological classification and tissue biomarkers of digestive neuroendocrine neoplasms: What the clinician should know

IF 6.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Best practice & research. Clinical endocrinology & metabolism Pub Date : 2023-09-01 DOI:10.1016/j.beem.2023.101795

Anne Couvelard (Pathologist) , Aurélie Cazes Pathologist , Jérôme Cros (Pathologist)

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Abstract

Histopathological classifications of neuroendocrine neoplasms (NEN) change regularly and the latest WHO classification published in 2022, which concerns all NEN in the body, attempts to standardize classifications in the different locations. Differentiation and proliferation mainly assessed by Ki-67 index are still the cornerstone of those classifications. However, many markers are now used for diagnostic (to check neuroendocrine differentiation, to identify the site of origin of a metastasis, to help separating high-grade neuroendocrine tumors/NET and neuroendocrine carcinoma/NEC), prognostic or theranostic purposes. NENs are often heterogeneous and this can lead to difficulties in classifications, biomarker and prognostic assessment. These different points are discussed successively in this review, insisting especially on the frequent digestive, gastro-entero-pancreatic (GEP) localizations.

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消化神经内分泌肿瘤的组织病理学分类和组织生物标志物的最新进展:临床医生应该知道的。

神经内分泌肿瘤（NEN）的组织病理学分类定期变化，2022年发布的最新世界卫生组织分类涉及体内所有NEN，试图将不同位置的分类标准化。主要通过Ki-67指数评估分化和增殖仍然是这些分类的基石。然而，许多标志物现在被用于诊断（检查神经内分泌分化，确定转移的起源部位，帮助分离高级神经内分泌肿瘤/NET和神经内分泌癌/NEC）、预后或治疗目的。NEN通常是异质性的，这可能导致分类、生物标志物和预后评估方面的困难。在这篇综述中，我们对这些不同的观点进行了连续的讨论，特别强调了常见的消化、胃肠-胰腺（GEP）定位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best practice & research. Clinical endocrinology & metabolism 医学-内分泌学与代谢

CiteScore

11.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.