Association between Serum Galectin-3 and Growth Differentiation Factor-15 Levels and Coronary Slow Flow Phenomenon.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Acta Cardiologica Sinica Pub Date : 2023-07-01 DOI:10.6515/ACS.202307_39(4).20221128A

Yasin Yuksel, Cennet Yıldız, Huri Bulut

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Abstract

Background: Coronary slow flow phenomenon (CSFP) is characterized by delay in the progression of contrast material in the coronary tree that is not accompanied by significant coronary artery narrowing. Pathophysiologic pathways underpinning CSFP still remain poorly understood.

Objectives: To evaluate the relationship between serum galectin-3 (GAL-3) and growth differentiation factor-15 (GDF-15) levels with CSFP.

Methods: Fifty CSFP patients and 40 subjects with normal coronary arteries were included in this retrospective study. The patients' serum GDF-15 and GAL-3 concentration levels were measured using relevant kits. Thrombolysis in myocardial infarction frame count (TFC) of each patients was determined.

Results: We did not find any differences with respect to clinical and demographic features between the two groups. GDF-15 and GAL-3 concentration levels were significantly higher in the patients with CSFP. Moreover GDF-15 and GAL-3 concentration levels were positively correlated with TFC (GDF-15; r = 0.448, GAL-3; r = 0.642, p < 0.001 for both). Multivariate logistic regression showed that GAL-3 and GDF-15 were predictors of the CSFP. Similarly, GDF-15 and GAL-3 were the only predictors of TFC. More specifically, GDF-15 and GAL-3 concentration levels of 182.18 pg/mL and 8.58 ng/mL predicted CSFP with sensitivities of 76% and 87.5%, respectively, and specificities of 84% and 75%, respectively.

Conclusions: GDF-15 and GAL-3 levels were increased in the CSFP patients and predicted the presence and severity of CSFP. Thus, these two biomarkers might prove useful in relation to the diagnosis of CSFP.

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血清半乳糖凝集素-3和生长分化因子-15水平与冠状动脉慢血流现象的关系

背景:冠状动脉慢血流现象(CSFP)的特征是冠脉树造影剂进展延迟，不伴有明显的冠状动脉狭窄。支持cfp的病理生理途径仍然知之甚少。目的:探讨血清半凝集素-3 (GAL-3)、生长分化因子-15 (GDF-15)水平与CSFP的关系。方法:50例CSFP患者和40例冠状动脉正常的受试者进行回顾性研究。采用相关试剂盒检测患者血清GDF-15、GAL-3浓度水平。测定每位患者的心肌梗死溶栓帧数(TFC)。结果:我们没有发现两组在临床和人口学特征方面有任何差异。GDF-15和GAL-3浓度水平在CSFP患者中显著升高。GDF-15和GAL-3浓度水平与TFC呈正相关(GDF-15;r = 0.448, GAL-3;R = 0.642, p < 0.001)。多因素logistic回归显示GAL-3和GDF-15是cspp的预测因子。同样，GDF-15和GAL-3是TFC的唯一预测因子。更具体地说，GDF-15和GAL-3浓度水平分别为182.18 pg/mL和8.58 ng/mL，预测CSFP的敏感性分别为76%和87.5%，特异性分别为84%和75%。结论:GDF-15和GAL-3水平在CSFP患者中升高，可预测CSFP的存在和严重程度。因此，这两个生物标志物可能被证明对cfp的诊断有用。

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来源期刊

Acta Cardiologica Sinica 医学-心血管系统

CiteScore

2.90

自引率

15.80%

发文量

144

审稿时长

>12 weeks

期刊介绍： Acta Cardiologica Sinica welcomes all the papers in the fields related to cardiovascular medicine including basic research, vascular biology, clinical pharmacology, clinical trial, critical care medicine, coronary artery disease, interventional cardiology, arrythmia and electrophysiology, atherosclerosis, hypertension, cardiomyopathy and heart failure, valvular and structure cardiac disease, pediatric cardiology, cardiovascular surgery, and so on. We received papers from more than 20 countries and areas of the world. Currently, 40% of the papers were submitted to Acta Cardiologica Sinica from Taiwan, 20% from China, and 20% from the other countries and areas in the world. The acceptance rate for publication was around 50% in general.