FOXP3 regulatory T cells on prognosis of breast cancer.

Breast disease Pub Date : 2023-01-01 DOI:10.3233/BD-239002

Andi Nilawati Usman, Mardiana Ahmad, Andi Wardihan Sinrang, Sartini Natsir, A B Takko, Andi Ariyandy, Ilhamuddin Ilhamuddin, Athira Rinandha Eragradini, Intan Idiana Hasan, Sabarisah Hasyim

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引用次数: 1

Abstract

Background: FOXP3 Tregs have been found in breast cancer patients, both humoral and tumor. Survival or prognosis of breast cancer patients seems to correlate with the increase and decrease in FOXP3 Treg.

Objectives: This review aims to provide insights regarding the FOXP3 Tregs involved and their mechanisms in breast cancer prognosis.

Methods: The literature study method is used from primary and secondary libraries. The library search used online-based search instruments such as NCBI-PubMed, Google Scholar, and Elsevier. The data obtained were then arranged according to the framework, data on the relationship between FOXP3 Regulatory T Cells and breast cancer, and writing a journal review was carried out according to the given format. Regulators (Tregs) can inhibit anti-tumor immunity and promote tumor growth. Tregs also play a role in inhibiting cytotoxic T lymphocyte cells by inhibiting the release of granules from CD8+, where CD8+ is important in killing tumor cells. FOXP3 is a Treg-specific biomarker and plays an important role in the development and function of Tregs.

Results: Studies on the presence of FOXP3+ Tregs in tumors have shown controversial results. Studies in some tumors reported the presence of FOXP3+, indicating a poor prognosis, whereas studies in other tumors found that FOXP3+ correlated with a good prognosis.

Conclusion: Regulatory T lymphocytes and TILs in invasive breast carcinoma are still not established. Therefore, further research on the Effect of FOXP3 expression of regulatory T lymphocytes on breast cancer is still important.

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FOXP3调节性T细胞对乳腺癌预后的影响。

背景:FOXP3 Tregs已在乳腺癌患者中发现，包括体液和肿瘤。乳腺癌患者的生存或预后似乎与FOXP3 Treg的升高或降低有关。目的:本综述旨在为FOXP3 Tregs在乳腺癌预后中的作用及其机制提供新的见解。方法:采用文献研究法，检索中小学图书馆资料。图书馆搜索使用了基于在线的搜索工具，如NCBI-PubMed、Google Scholar和Elsevier。然后将获得的数据按照框架进行整理，FOXP3调节性T细胞与乳腺癌关系的数据，并按照给定的格式撰写期刊综述。Tregs具有抑制抗肿瘤免疫、促进肿瘤生长的作用。Tregs还通过抑制CD8+颗粒的释放来抑制细胞毒性T淋巴细胞，其中CD8+在杀死肿瘤细胞中起重要作用。FOXP3是treg特异性生物标志物，在treg的发育和功能中起重要作用。结果:关于FOXP3+ Tregs在肿瘤中的存在的研究显示出有争议的结果。在一些肿瘤研究中报道FOXP3+的存在，提示预后不良，而在其他肿瘤研究中发现FOXP3+与预后良好相关。结论:在浸润性乳腺癌中，调节性T淋巴细胞与TILs的关系尚不明确。因此，进一步研究调节性T淋巴细胞FOXP3表达对乳腺癌的影响仍具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.