Galectin-3 is Associated with Heart Failure Incidence: A Meta-Analysis.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2023-01-01 DOI:10.2174/1573403X19666221117122012
Basil M Baccouche, Mattia A Mahmoud, Corrine Nief, Karan Patel, Barbara Natterson-Horowitz
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Abstract

Introduction: Heart failure (HF) is a leading cause of death worldwide. The global prevalence of heart failure is projected to increase rapidly in the coming decades, and significant attention has turned to improving biomarker-based risk prediction of incident HF. This paper aimed to qualitatively and quantitatively evaluate the evidence associating levels of galectin-3 with the risk of incident HF.

Methods: A review of PUBMED-indexed peer-reviewed literature was performed. Nine studies met the inclusion criteria, and all nine had data eligible for conversion and pooling. A randomeffects meta-analysis was performed using hazard ratios and 95% confidence intervals from a minimally adjusted model, a further adjusted model, and from subgroups within the further-adjusted model.

Results: The minimally-adjusted model provided an HR of 1.97 (95% CI 1.74-2.23) when comparing the top quartile of log-gal-3 to the bottom quartile. The further-adjusted model provided an HR of 1.32 (95% CI 1.21-1.44) for the same comparison. The positive, significant association was conserved during sensitivity analysis.

Conclusion: There is a significant positive association between circulating galectin-3 and the risk of incident heart failure. Given the complex mechanistic relationship between galectin-3 and cardiovascular pathophysiology, further investigation is recommended for the possible implementation of galectin-3 into clinical risk prediction models.

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半乳糖凝集素-3与心力衰竭发病率相关:荟萃分析。
引言:心力衰竭(HF)是世界范围内死亡的主要原因。预计在未来几十年,全球心力衰竭的患病率将迅速上升,人们的注意力已转向改进基于生物标志物的HF事件风险预测。本文旨在定性和定量评估半乳糖凝集素-3水平与HF发病风险相关的证据。方法:回顾PUBMED索引的同行评审文献。九项研究符合纳入标准,所有九项研究的数据都符合转换和汇总的条件。使用最小调整模型、进一步调整模型和进一步调整模型内的亚组的风险比和95%置信区间进行随机效应荟萃分析。结果:当比较log-gal-3的上四分位数和下四分位数时,最小调整模型的HR为1.97(95%CI 1.74-2.23)。对于相同的比较,进一步调整的模型提供了1.32的HR(95%CI 1.21-1.44)。在敏感性分析中,阳性、显著的关联是保守的。结论:循环中的半乳糖凝集素-3与发生心力衰竭的风险之间存在显著的正相关。鉴于半乳糖凝集素-3与心血管病理生理学之间的复杂机制关系,建议进一步研究半乳糖凝集素3在临床风险预测模型中的可能应用。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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