Quantitative Value of Bacteria Associated with Leukocytes in Differential Diagnosis of Lower Respiratory Tract Infection in Children, in Comparison to Sputum Culture and Procalcitonin.

Laboratory medicine Pub Date : 2024-01-06 DOI:10.1093/labmed/lmad035

Guoqiang Zhang, Yihui Yao, Ying Gao, Xiaolu Yu, Jiabin Fang

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Abstract

Background: The mortality and morbidity rates in children with lower respiratory tract infection (LRTI) remain high.

Objective: To describe the number of bacteria that is associated with leukocytes in differential diagnosis of bacterial, mycoplasma, and viral LRTI in children.

Methods: Sputum smears were Gram stained for counting single-morphology bacteria associated with leukocytes. The differential diagnostic values of bacterial number were assessed in children with LRTI.

Results: The area under the receiver operating characteristic (ROC) curve was 0.95 for bacterial number in the differential diagnosis of bacterial infection from mycoplasma and viral infections. The area under the ROC curve was 0.62 for procalcitonin and 0.94 for bacterial number in the differential diagnosis of bacterial infection from mycoplasma infection.

Conclusion: The number of bacteria associated with leukocytes in sputum was valuable and rapid in differential diagnosis of bacterial infection in children with suspected bacterial, mycoplasma, and viral LRTI.

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与痰培养和降钙素原相比，白细胞伴生细菌在儿童下呼吸道感染鉴别诊断中的定量价值。

背景：儿童下呼吸道感染（LRTI）的死亡率和发病率居高不下：下呼吸道感染（LRTI）患儿的死亡率和发病率居高不下：描述在鉴别诊断儿童细菌性、支原体性和病毒性下呼吸道感染时与白细胞相关的细菌数量：方法：对痰涂片进行革兰氏染色，计数与白细胞相关的单形态细菌。方法：对痰涂片进行革兰氏染色，计数与白细胞相关的单形态细菌，评估细菌数量对 LRTI 儿童的鉴别诊断价值：结果：在细菌感染与支原体和病毒感染的鉴别诊断中，细菌数的接收者操作特征曲线下面积为 0.95。在细菌感染与支原体感染的鉴别诊断中，降钙素原的 ROC 曲线下面积为 0.62，细菌数的 ROC 曲线下面积为 0.94：结论：痰液中与白细胞相关的细菌数对疑似细菌、支原体和病毒性 LRTI 患儿的细菌感染鉴别诊断有价值且快速。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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