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{"title":"From Beneath the Skin to the Airway Wall: Understanding the Pathological Role of Adipose Tissue in Comorbid Asthma-Obesity.","authors":"Carolyn J Wang, Peter B Noble, John G Elliot, Alan L James, Kimberley C W Wang","doi":"10.1002/cphy.c220011","DOIUrl":null,"url":null,"abstract":"<p><p>This article provides a contemporary report on the role of adipose tissue in respiratory dysfunction. Adipose tissue is distributed throughout the body, accumulating beneath the skin (subcutaneous), around organs (visceral), and importantly in the context of respiratory disease, has recently been shown to accumulate within the airway wall: \"airway-associated adipose tissue.\" Excessive adipose tissue deposition compromises respiratory function and increases the severity of diseases such as asthma. The mechanisms of respiratory impairment are inflammatory, structural, and mechanical in nature, vary depending on the anatomical site of deposition and adipose tissue subtype, and likely contribute to different phenotypes of comorbid asthma-obesity. An understanding of adipose tissue-driven pathophysiology provides an opportunity for diagnostic advancement and patient-specific treatment. As an exemplar, the potential impact of airway-associated adipose tissue is highlighted, and how this may change the management of a patient with asthma who is also obese. © 2023 American Physiological Society. Compr Physiol 13:4321-4353, 2023.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"13 1","pages":"4321-4353"},"PeriodicalIF":4.2000,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220011","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
This article provides a contemporary report on the role of adipose tissue in respiratory dysfunction. Adipose tissue is distributed throughout the body, accumulating beneath the skin (subcutaneous), around organs (visceral), and importantly in the context of respiratory disease, has recently been shown to accumulate within the airway wall: "airway-associated adipose tissue." Excessive adipose tissue deposition compromises respiratory function and increases the severity of diseases such as asthma. The mechanisms of respiratory impairment are inflammatory, structural, and mechanical in nature, vary depending on the anatomical site of deposition and adipose tissue subtype, and likely contribute to different phenotypes of comorbid asthma-obesity. An understanding of adipose tissue-driven pathophysiology provides an opportunity for diagnostic advancement and patient-specific treatment. As an exemplar, the potential impact of airway-associated adipose tissue is highlighted, and how this may change the management of a patient with asthma who is also obese. © 2023 American Physiological Society. Compr Physiol 13:4321-4353, 2023.
从皮肤下到气道壁:了解脂肪组织在哮喘-肥胖共病中的病理作用。
这篇文章提供了一份关于脂肪组织在呼吸功能障碍中的作用的当代报告。脂肪组织分布在全身各处,在皮肤下(皮下)、器官周围(内脏)积聚,而且在呼吸道疾病的情况下,最近被证明在气道壁内积聚:“气道相关脂肪组织”。过多的脂肪组织沉积会损害呼吸功能,增加哮喘等疾病的严重程度。呼吸损伤的机制在本质上是炎症性、结构性和机械性的,根据沉积的解剖部位和脂肪组织亚型而有所不同,并可能导致哮喘-肥胖共病的不同表型。对脂肪组织驱动的病理生理学的理解为诊断进步和患者特异性治疗提供了机会。作为一个例子,气道相关脂肪组织的潜在影响被强调,以及这可能如何改变哮喘患者同时肥胖的管理。©2023美国生理学会。中国生物医学工程学报(英文版),2023。
本文章由计算机程序翻译,如有差异,请以英文原文为准。